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ID 48712
フルテキストURL
著者
Nakagawa, Shinya Graduate School of Health Sciences, Okayama University
Kataoka, Takahiro Graduate School of Health Sciences, Okayama University
Mizuguchi, Yuko Graduate School of Health Sciences, Okayama University
Yoshimoto, Masaaki Graduate School of Health Sciences, Okayama University
Sakoda, Akihiro Graduate School of Health Sciences, Okayama University
Nomura, Takaharu Radiation Safety Research Center, Central Research Institute of Electric Power Industry
Wang, Da-Hong Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Kawabe, Atsushi Graduate School of Health Sciences, Okayama University
Taguchi, Takehito Graduate School of Health Sciences, Okayama University
Yamaoka, Kiyonori Graduate School of Health Sciences, Okayama University
抄録
To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. The catalase activities in livers and spleens of acatalasemic mice were significantly lower than those of normal mice and the glutathione peroxidase activity in livers of acatalasemic mice was significantly higher than that of normal mice. At 10 days after 6.0 Gy irradiation, the catalase activities in livers of acatalasemic and normal mice and that in spleens of normal mice significantly decreased compared with no-irradiation control, and there were no differences between those catalase activities. The total glutathione content in acatalasemic mice was significantly higher than that in normal mice at 10 days after 6.0 Gy irradiation. These findings suggested that the radiosensitivity of acatalasemic mice in terms of whole body irradiation doesn’t significantly differ from that of normal mice, probably due to compensated sufficient contents of glutathione peroxidase and total glutathione in acatalasemic mice.
キーワード
acatalasemic mouse
radiosensitivity
catalase
glutathione peroxidase
total glutathione
発行日
2008-07
出版物タイトル
Journal of Clinical Biochemistry and Nutrition
43巻
1号
出版者
The Editorial Secretariat of JCBN
開始ページ
41
終了ページ
49
ISSN
0912-0009
NCID
AA10710201
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/jcbn/43/1/43_2008042/_article
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/21480
言語
English
OAI-PMH Set
岡山大学
著作権者
Copyright © 2008 by The Editorial Secretariat of JCBN
論文のバージョン
publisher
査読
有り
DOI
Web of Sience KeyUT