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ID 3601
Eprint ID
3601
フルテキストURL
Thumnail O001732.pdf 371 KB
タイトル(別表記)
肝疾患で減少した血漿フィブロネクチンは肝組織の線維化,炎症及び壊死の程度に相関した
著者
治徳 通博 岡山大学
抄録
We applied a modified enzyme-linked immunosorbent assay (ELISA) for the measurement of human plasma fibronectin and determined the level of plasma fibronectin in 90 patients with various liver diseases and 10 normal subjects. Diagnoses were made by liver biopsy under peritoneoscopy. Plasma fibronectin was significantly decreased in liver cirrhosis patients, but not in acute hepatitis or chronic hepatitis patients. Decreased plasma fibronectin was correlated poorly with 18 laboratory tests, including liver function tests, and inflammatory marker determinations performed prior to peritoneoscopy. A correlation was found between the decreased plasma fibronectin and the severity of fibrotic, inflammatory and necrotic changes of the liver. These results suggested that the level of plasma fibronectin may reflect the severity of tissue injury resulting from chronic liver diseases.
キーワード
plasma fibronectin
liver diseases
liver biopsy
備考
掲載順位 130 ; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3766203&dopt=Abstract
発行日
1986-12-31
出版物タイトル
資料タイプ
学位論文
学位授与番号
乙第1732号
学位授与年月日
1986-12-31
学位・専攻分野
博士(医学)
授与大学
岡山大学
オフィシャル URL
http://escholarship.lib.okayama-u.ac.jp/cgi/viewcontent.cgi?article=1985&context=amo
言語
Japanese
論文のバージョン
none
査読
不明