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ID 17529
Eprint ID
17529
フルテキストURL
Thumnail 85_9.pdf 1.17 MB
タイトル(別表記)
Studies on the treatment of malignant tumors with fibroblast-inhibiting agents Part Ⅱ. Effects of chloroquine on tumor-bearing animals (Bashford cancer)
著者
渋谷 貢一 岡山大学平木内科
抄録
Chloroquine diphosphate, as demonstrated to be a fibroblast-inhibiting agent, was employed in an attempt to suppress the growth of cancer indirectly by inhibiting the interstitial connective tissue of cancer. Bashford cancer which is relatively rich in the interstitium was tested with this agent and the following results were obtained. 1) Chloroquine diphosphate clearly retarded the growth of Bashford cancer. The daily intraperitoneal dose of 25mg/kg was more effective than 10mg/kg. 2) The life span of the tumor-bearing animals was slightly prolonged as compared to controls. 3) The above data were supported by the collateral experimental results; an increase of tumor tissue necrosis as shown by histological and histochemical studies, a decrease of connective tissue elements and acid mucopolysaccharide, inhibition of lowering of liver catalase activity, and a decrease of iron in the tumor and other organs.
発行日
1973-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
85巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
9
終了ページ
14
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/85/1-2/85_1-2_9/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma