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ID 17531
Eprint ID
17531
フルテキストURL
Thumnail 85_23.pdf 7.22 MB
タイトル(別表記)
Studies on the treatment of malignant tumors with fibroblast-inhibiting agents Part Ⅳ. Effects of chloroquine on human tumors
著者
渋谷 貢一 岡山大学平木内科
抄録
An fibroblast-inhibiting agent, chloroquine was administered to cancer patients and the following results were obtined. 1) Chloroquine diphosphate and chloroquine diorotate was given to 54 patients with histologically proven cancers of these it was effective in 38, non-effective in 15 and unknown in 1. The drug was particularly effective in lung cancer (12/13) and bladder cancer (6/8). In effective cases, there were alleviation of pain and improvement anemia, blood sedimention rate, serum protein and serum iron. Tumor regression often occurred and histologically, tendency of tumor necrosis and inhibition of interstitial connective tissue were observed. 2) The side effects of chloroquine were silght and 8 of 54 patients treated showed slight gastrointestinal, neurological or eye complaints. Hematopoiesis was not impaired. 3) The mechanism of action of this agent seems to be in the inhibition of cancer stromal connective tissue, anti-inflamatory and constiutional humoral effects. 4) Therefore, the indication of this drug includes inoperable cases, pre-and post-operative cases, especially in those who failed to respond to ordinary anti-cancer agents.
発行日
1973-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
85巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
23
終了ページ
34
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/85/1-2/85_1-2_23/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma