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ID 16571
Eprint ID
16571
フルテキストURL
Thumnail 93_499.pdf 1.72 MB
タイトル(別表記)
Studies on human peripheral monocyte chemotaxis Part II. Monocyte chemotaxis in patients with bronchogenic carcinoma
著者
片岡 幹男 岡山大学医学部第二内科教室
抄録
The chemotactic responsiveness of peripheral blood monocytes was measured in 71 patients with bronchogenic carcinoma, 13 patients with sarcoidosis, 14 patients with pulmonary tuberculosis and 91 normal controls. The monocyte chemotactic response (MCR) was significantly depressed in patients with bronchogenic carcinoma (mean=19.6±6.6,P<0.001) as compared to normal controls (mean=33.7±7.4). On the other hand, MCR was significantly enhanced in patients with pulmonary tuberculosis (mean=41.6±7.9,P<0.01). There was no significant difference from normal controls in patients with sarcoidosis (mean=27.5±8.5). In bronchogenic carcinoma patients, depression of the MCR was observed in all clinical stages. The MCR was further depressed in patients with evidence of distant metastasis compared to those without metastasis. There was no significant correlation between the MCR and histologic types of tumors. The MCR was significantly lowered by combination chemotherapy in 21 cases who received chemotherapy, but was elevated in 5 of 6 patients who had a remission after combination chemotherapy. These data showed that monocyte function in patients with bronchogenic carcinoma was suppressed, and suggested that malignant tumors themselves might affect monocyte function.
キーワード
monocyte
chemotaxis
bronchogenic carcinoma
chemotherapy
発行日
1981-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
93巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
499
終了ページ
506
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/93/5-6/93_5-6_499/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
3
Eprints Journal Name
joma