JaLCDOI 10.18926/AMO/32044
フルテキストURL fulltext.pdf
著者 Kimura, Ikuro| Ohnoshi, Taisuke| Nakata, Yasunari| Takasugi, Kenta| Fujii, Masafumi| Hayashi, Kyoichi| Kataoka, Mikio| Sato, Masaharu| Nishihara, Ryuji|
抄録 <p>Clinical trials of immuno-chemotherapy were conducted on malignant lymphoma patients. Patients during the period from 1972 through 1977 were allocated to two groups retrospectively according to the mode of treatment, i.e., chemotherapy alone (historical control group, 35 patients) and chemotherapy with OK-432 (treated group, 15 patients). Comparisons were made of the two groups, which were homogeneous with regard to induction chemotherapy, maintenance chemotherapy, stage and histologic type of disease. The treated group had a higher remission rate, and a longer remission duration and survival than the control groups, especially in patients with Hodgkin's disease but the difference was not statistically significant owing to the limited number of cases.</p>
キーワード malignant lymphoma chemotherapy nonspecific immunotherapy OK-432
Amo Type Article
発行日 1979-12
出版物タイトル Acta Medica Okayama
33巻
6号
出版者 Okayama University Medical School
開始ページ 471
終了ページ 478
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 94239
NAID 120002311472
JaLCDOI 10.18926/AMO/31929
フルテキストURL fulltext.pdf
著者 Nakata, Yasunari| Ejiri, Togo| Kishi, Toshiyuki| Mori, Yoshihiro| Hioka, Tohru| Kataoka, Mikio| Ohnoshi, Taisuke| Kimura, Ikuro|
抄録 <p>The proliferation of lymphocytes induced by Propionibacterium acnes (P. acnes) was measured by the in vitro incorporation of 3H-thymidine. The mean response rate of alveolar lymphocytes obtained by bronchoalveolar lavage was 2.23 +/- 0.89 in nine untreated sarcoidosis patients, 0.85 +/- 0.17 in five sarcoidosis patients given corticosteroids and 0.78 +/- 0.29 in 11 controls. The proliferation was significantly enhanced in the untreated patients compared to both the treated patients (p less than 0.01) and controls (p less than 0.001), but there was no significant difference in response rates between the treated patients and controls. The response rate of alveolar lymphocytes was significantly higher in four active patients (3.05 +/- 0.61) than in four inactive patients (1.77 +/- 0.44) (p less than 0.05) and in the controls (p less than 0.001). In sarcoidosis patients, the response rates showed a good correlation with activities of serum lysozyme (r = 0.695, p less than 0.01), and with percentages of lymphocytes in bronchoalveolar lavage fluid (r = 0.591, p less than 0.05). There was a low correlation between angiotensin-converting enzyme activities and the response rates (r = 0.508, p less than 0.1). Neither peripheral blood lymphocytes in sarcoidosis patients nor in controls showed any response to P. acnes, but alveolar lymphocytes of the untreated active sarcoidosis patients were sensitive to P. acnes. The lymphocytes activated by P. acnes may play a central role in the induction of alveolitis in sarcoidosis patients.</p>
キーワード sarcoidosis alveolar lymphocyte lymphocyte proliferation Propionibacterium acnes
Amo Type Article
発行日 1986-10
出版物タイトル Acta Medica Okayama
40巻
5号
出版者 Okayama University Medical School
開始ページ 257
終了ページ 264
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3024453
Web of Sience KeyUT A1986E557800004
JaLCDOI 10.18926/AMO/32676
フルテキストURL fulltext.pdf
著者 Hosoya, Shigee| Kataoka, Mikio| Nakata, Yasunari| Maeda, Tsuyoshi| Nishizaki, Hiroshi| Hioka, Tohru| Mori, Yoshihiro| Ejiri, Tougo| Shiomi, Katsuhiko| Ueoka, Hiroshi| Numata, Takeyuki| Nishii, Kenji| Kodani, Tsuyoshi| Moritani, Yoshiaki| Ohnoshi, Taisuke| Kimura, Ikuro|
抄録 <p>Clinical features were studied in 125 patients with sarcoidosis (72 females and 53 males) diagnosed at Okayama University Hospital during a recent 10-year period. The age distribution had two peaks in patients in their 20s and the 50s. Over half of the patients were detected at health screening check and were asymptomatic, while the remaining were symptomatic. Twelve patients were in stage 0, 41 were in stage I, 54 were in stage II, 16 were in stage III, and 2 were in stage IV according to the chest x-ray findings. Serum angiotensin converting enzyme levels and serum lysozyme levels were elevated in 60% and 76% of the patients, respectively. The bronchoalveolar lavage fluid showed lymphocytosis, especially of helper T-cells. The clinical features of sarcoidosis appear to depend on the duration of the disease.</p>
キーワード sarcoidosis serum angiotesin converting enzyme bronchoalveolar lavage
Amo Type Article
発行日 1992-02
出版物タイトル Acta Medica Okayama
46巻
1号
出版者 Okayama University Medical School
開始ページ 31
終了ページ 36
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1561903
Web of Sience KeyUT A1992HH01700006
JaLCDOI 10.18926/AMO/30510
フルテキストURL fulltext.pdf
著者 Matsuo, Kiyoshi| Tada, Shinya| Shibayama, Takuo| Ueno, Yoshiki| Miyake, Toshitugu| Takehara, Hideki| Kataoka, Mikio| Harada, Mine| Kimura, Ikuro|
抄録 <p>&#60;P&#62;Idiopathic interstitial pneumonia (IIP) is a progressive and often fatal pulmonary disorder, and evaluating the prognosis of patients with IIP has never been sufficient. Accordingly, factors including clinical features, laboratory data, cellular components in bronchoalveolar lavage (BAL) fluid and response to corticosteroid therapy were analyzed in 35 patients with IIP whose median age of respiratory onset was 60 years (range; 37-77 years). Nineteen patients (54.3%) were in the active stage of IIP and 16 of them were treated with corticosteroids. Significant prognostic factors were the neutrophil percentage in BAL fluid, interstitial shadows on chest radiograph, pulmonary function, blood oxygen level, grade of dyspnea, and disease activity at the initial examination. Patients in the active stage showed higher proportions of neutrophils and eosinophils in BAL fluid than those in the non-active stage. Despite corticosteroid therapy, the survival of patients in the active stage was significantly shorter than those in the non-active stage. Fifty percent of the patients treated with corticosteroids were regarded as responders at 1 month after the initiation of therapy; however, there was no significant difference between responders and non-responders in terms of survival time. In conclusion, disease activity and neutrophils in BAL fluid may be important predictors of the prognosis of IIP.&#60;/P&#62;</p>
キーワード idiopathic interstitial pneumonia (LLP) prognostic factor corticosteroid therapy bronchoalveolar lavage(BAL) disease activity
Amo Type Article
発行日 1996-02
出版物タイトル Acta Medica Okayama
50巻
1号
出版者 Okayama University Medical School
開始ページ 37
終了ページ 46
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8701780
Web of Sience KeyUT A1996TY06000006
JaLCDOI 10.18926/AMO/32009
フルテキストURL fulltext.pdf
著者 Ohke, Masashi| Tada, Shinya| Nabe, Makoto| Matsuo, Kiyoshi| Kataoka, Mikio| Harada, Mine|
抄録 <p>Allergic and chronic inflammation of the airway is regarded as the main pathogenesis of bronchial asthma, in which adhesion of inflammatory cells requires the expression of adhesion molecules. Thus, to clarify the role of fibronectin (FN) in the airway inflammation of bronchial asthma, FN levels in plasma and bronchoalveolar lavage fluid (BALF) from bronchial asthmatics were determined. FN concentrations in plasma and BALF were measured by enzyme-linked immunosorvent assay (ELISA) in 17 asthmatic patients and 10 healthy controls to elucidate the role of FN in allergic inflammation. The mean FN/albumin (Alb) level in the BALF of asthmatic patients was 2.973 micrograms/mg, which was significantly higher than that of healthy controls (0.727 microgram/mg). Non-atopic asthmatics showed a significantly higher level of FN in their BALF in comparison with atopic asthmatics, although the ratio of FN to albumin showed no significant difference. FN levels in BALF correlated significantly with total cell density (r = 0.71, P &#60; 0.05) and alveolar macrophage density (r = 0.64, P &#60; 0.05). FN levels in plasma did not correlate with those in BALF. In conclusion, increased FN in BALF, which was produced locally in the airways of asthmatic patients, is actively involved in the regulation of allergic inflammation.</p>
キーワード airway inflammation adhesion molecule bronchoalveolar lavage fluid bronchial asthma fibronectin
Amo Type Article
発行日 2001-04
出版物タイトル Acta Medica Okayama
55巻
2号
出版者 Okayama University Medical School
開始ページ 83
終了ページ 89
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11332203
Web of Sience KeyUT 000168195700004
JaLCDOI 10.18926/AMO/31991
フルテキストURL fulltext.pdf
著者 Takehara, Hideki| Tada, Shinya| Kataoka, Mikio| Matsuo, Kiyoshi| Ueno, Yoshiki| Ozaki, Shinji| Miyake, Toshitsugu| Fujimori, Yoshiaki| Yamadori, Ichiro| Harada, Mine|
Amo Type Article
発行日 2001-08
出版物タイトル Acta Medica Okayama
55巻
4号
出版者 Okayama University Medical School
開始ページ 205
終了ページ 211
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
Web of Sience KeyUT 000170367200002
JaLCDOI 10.18926/AMO/32852
フルテキストURL fulltext.pdf
著者 Iio, Kouji| Iio, Tomoe Ueno| Okui, Yuhei| Ichikawa, Hirohisa| Tanimoto, Yasushi| Miyahara, Nobuaki| Kanehiro, Arihiko| Tanimoto, Mitsune| Nakata, Yasunari| Kataoka, Mikio|
抄録 <p>Propionibacterium acnes has been implicated as an etiologic agent of sarcoidosis since the isolation of this bacterium from sarcoid lesions. We experimentally produced a murine pulmonary granuloma model using P. acnes with several features that simulate sarcoidosis. Mice were sensitized with heat-killed P. acnes and complete Freund's adjuvant and were subsequently challenged with heat-killed P. acnes at 2-week intervals. P. acnes-challenged mice developed epitheloid cell granulomas in the lungs. These mice showed a pulmonary immune response characterized by an increased number of T-lymphocytes, especially CD4 cells, and the ratio of CD4/CD8 in bronchoalveolar lavage (BAL) fluid also increased. Furthermore, significant elevations in both angiotensin-converting enzyme (ACE) serum levels and antibody titers against P. acnes were observed. Mice sensitized with P. acnes without complete Freund's adjuvant were capable of forming pulmonary granulomas, which appeared to be caused by indigenous P. acnes. The genome of P. acnes was found in the lungs, BAL cells, hilar lymph nodes, liver, and spleen in non-sensitized mice, which were thought to be germ-free. These results suggest that the immune response against indigenous P. acnes may play an important role in the pathogenesis of granuloma formation in a murine model.</p>
キーワード Propionibacterium acnes experimental granuloma sarcoidosis
Amo Type Original Article
発行日 2010-04
出版物タイトル Acta Medica Okayama
64巻
2号
出版者 Okayama University Medical School
開始ページ 75
終了ページ 83
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 20424662
Web of Sience KeyUT 000276996900001
JaLCDOI 10.18926/AMO/48963
フルテキストURL 66_5_387.pdf
著者 Chikasue, Kumiko| Kimura, Miyuki| Ikeda, Kazuyuki| Ohnishi, Takuma| Kawanishi, Satoshi| Iio, Tomoe| Kataoka, Mikio| Arao, Yujiro|
抄録 To determine whether exhaled breath contains Torque teno virus (TTV) or not, we tested exhaled breath condensate (EBC) samples by semi-nested PCR assay. We detected TTV DNA in 35% (7/20) of EBC samples collected from the mouth of one of the authors, demonstrating that TTV DNA is excreted in exhaled breath with moderate frequency. TTV DNA was detected also in oral EBC samples from 4 of 6 other authors, indicating that TTV DNA excretion in exhaled breath is not an exception but rather a common phenomenon. Furthermore, the same assay could amplify TTV DNA from room air condensate (RAC) samples collected at distances of 20 and 40cm from a human face with 40 (8/20) and 35% (7/20) positive rates, respectively. TTV transmission has been reported to occur during infancy. These distances seem equivalent to that between an infant and its household members while caring for the infant. Taken together, it seems that exhaled breath is one of the possible transmission routes of TTV. We also detected TTV DNA in 25% (10/40) of RAC samples collected at a distance of more than 180cm from any human face, suggesting the risk of airborne infection with TTV in a room.
キーワード Torque teno virus exhaled breath airborne infection polymerase chain reaction
Amo Type Original Article
発行日 2012-10
出版物タイトル Acta Medica Okayama
66巻
5号
出版者 Okayama University Medical School
開始ページ 387
終了ページ 397
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23093057
Web of Sience KeyUT 000310253900003
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/49508
著者 Kurimoto, Etsuko| Miyahara, Nobuaki| Kanehiro, Arihiko| Waseda, Koichi| Taniguchi, Akihiko| Ikeda, Genyo| Koga, Hikari| Nishimori, Hisakazu| Tanimoto, Yasushi| Kataoka, Mikio| Iwakura, Yoichiro| Gelfand, Erwin W.| Tanimoto, Mitsune|
発行日 2013-01-20
出版物タイトル Respiratory Research
14巻
資料タイプ 学術雑誌論文
著者 Koga, Hikari| Miyahara, Nobuaki| Fuchimoto, Yasuko| Ikeda, Genyo| Waseda, Koichi| Ono, Katsuichiro| Tanimoto, Yasushi| Kataoka, Mikio| Gelfand, Erwin W.| Tanimoto, Mitsune| Kanehiro, Arihiko|
発行日 2013-01-24
出版物タイトル Respiratory Research
14巻
資料タイプ 学術雑誌論文
著者 片岡 幹男|
発行日 1981-06-30
出版物タイトル 岡山医学会雑誌
93巻
5-6号
資料タイプ 学術雑誌論文
著者 片岡 幹男|
発行日 1981-06-30
出版物タイトル 岡山医学会雑誌
93巻
5-6号
資料タイプ 学術雑誌論文
著者 中田 安成| 片岡 幹男| 平松 順一| 岡崎 和徳| 原田 実根|
発行日 1998-09-30
出版物タイトル 岡山大学医療技術短期大学部紀要
9巻
1号
資料タイプ 紀要論文
著者 岡本 誠| 芦田 耕三| 光延 文裕| 御舩 尚志| 保崎 泰弘| 柘野 浩史| 原田 誠之| 湯本 英一朗| 高田 真吾| 谷崎 勝朗| 片岡 幹男| 原田 実根|
発行日 1998-12
出版物タイトル 岡大三朝分院研究報告
69巻
資料タイプ 紀要論文
著者 岡本 誠| 光延 文裕| 芦田 耕三| 御舩 尚志| 保崎 泰弘| 柘野 浩史| 原田 誠之| 高田 真吾| 谷崎 勝朗| 片岡 幹男| 新谷 憲治| 原田 実根|
発行日 1999-12
出版物タイトル 岡大三朝分院研究報告
70巻
資料タイプ 紀要論文
著者 中田 安成| 森 由弘| 江尻 東伍| 片岡 幹男| 平松 順一|
発行日 1995-01-31
出版物タイトル 岡山大学医療技術短期大学部紀要
5巻
資料タイプ 紀要論文
著者 中田 安成| 片岡 幹男| 木村 郁郎|
発行日 1993-01-31
出版物タイトル 岡山大学医療技術短期大学部紀要
3巻
資料タイプ 紀要論文
著者 片岡 幹男|
発行日 1982-03-31
出版物タイトル
資料タイプ 学位論文