このエントリーをはてなブックマークに追加
ID 14233
Eprint ID
14233
フルテキストURL
タイトル(別表記)
Studies on immunoprophylactic effects of OK-432 and Ge-132 on methylcholanthrene-induced mouse sarcoma Part 1. Suppressive effects of OK-432 and Ge-132 with respect to timing of administration, and the role of natural killer cells
著者
玉井 守 岡山大学医学部第二内科学教室
抄録
C3H mice were subcutaneously (s.c.) injected with a tumorigenic dose (1mg/mouse) of 3-methylcholanthrene (MC) and tumor development was observed for 18 weeks. OK-432 or Ge-132 was intraperitoneally administered either after MC injection (post-treatment) or both before and after MC injection (pre- and post-treatment). Pre- and post-treatment with OK-432 significantly inhibited the development of tumors from 10 to 12 weeks after MC injection as compared with a control group. In all of the groups, the incidence of tumors was 100 percent 18 weeks after MC injection. With respect to Ge-132, both post-treatment and pre- and post-treatment administration reduced tumor growth in a similar manner to pre- and post-treatment of OK-432. After pre-treatment with OK-432 or Ge-132 for two weeks, the percentage of large granular lymphocytes in peripheral blood and the natural killer activity of splenic cells in mice were increased. These results suggest that the immune status plays an important role in the defense mechanisms against chemically-induced tumors.
キーワード
Methylcholanthrene-induced sarcoma
OK-432
Ge-132
NK cell
備考
原著
発行日
1992-12
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
104巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1007
終了ページ
1014
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/104/11-12/104_11-12_1007/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma