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ID 14235
Eprint ID
14235
フルテキストURL
Thumnail 104_1015.pdf 1.86 MB
タイトル(別表記)
Studies on immunoprophylactic effects of OK-432 and Ge-132 on methylcholanthrene-induced mouse sarcoma Part 2. The role of effector cells in antitumor activity of OK-432 and Ge-132
著者
玉井 守 岡山大学医学部第二内科学教室
抄録
The suppressive effects of OK-432 and Ge-132 on 3-methylcholanthrene (MC) carcinogenesis have been confirmed. To clarify the mechamism of this suppression, we investigated the effects of anti-asialo GM1 antibody (AGM1), anti-thymocyte antibody (Thy) and carrageenan (CAR), which eliminate NK cells, T cells and macrophages, respectively, on the growth of MC induced sarcoma. The suppressive effect of Ge-132 in mice was abolished by prior AGM1, Thy or CAR treatment ; moreover, these compounds enhanced the development of tumors. In mice treated with OK-432, AGM1 or CAR enhanced the development of tumors, as well ; however, Thy treatment did not alter tumor incidence. Prior treatment with AGM1 reduced the percentage of large granular lymphocytes and NK activity, which were increased by OK-432 or Ge-132 treatment ; however, Thy or CAR did not alter these parameters. These results indicate that NK cells and macrophages play an important role in the defense against MC induced sarcoma in OK-432-treated mice, while T cells as well as NK cells and macrophages do so in Ge-132-treated mice.
キーワード
Methylcholanthrene-induced sarcoma
NK cell
T cell
Macrophage
備考
原著
発行日
1992-12
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
104巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1015
終了ページ
1022
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/104/11-12/104_11-12_1015/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
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言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
2
Eprints Journal Name
joma