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ID 14409
Eprint ID
14409
フルテキストURL
Thumnail 104_387.pdf 2.66 MB
タイトル(別表記)
Studies on transferrin receptor of macrophages in iron metabolism Part 2. Regulation of tranferrin receptors on alveolar macorophages in iron-overloaded and iron-deficient conditions
著者
稲田 俊雄 岡山大学医学部第二内科学教室
抄録
Transferrin receptors (TfR) are involved in the first step of iron uptake into cells. To clarify the changes in TfR under various conditions, radiobinding assay of (125)I-labeled iron-saturated transferrin was performed in alveolar macrophages from 2 patients with idiopathic hemo-chromatosis and iron-overloaded or iron-deficient guinea pigs. Patients with idiopathic hemochromatosis showed a reduction in the Fe-TfR count on alveolar macrophages (5.0×10(4)/cell) as compared to that in healthy individuals (19.88±8.19×10(4)/cell). Concerning the Fe-TfR binding constant, no differnce was observed between patients with idiopathic hemochromatosis and healthy controls. The Fe-TfR count on alveolar macrophages was significantly lower in iron-overloaded guined pigs than in normal cntrols. The count was significantly elevated in iron-deficient guinea pigs. Concerning the Fe-TfR binding constant, none of the iron-overloaded and iron-deficient groups showed any significant difference from the normal controls. These findings suggest that experimentally-induced iron overload and iron deficiency may be autoregulated by intracellular iron levels.
キーワード
Transferrin receptor
Hemochromatotis
Iron overloaded
Iron depleted Alveolar macrophage
発行日
1992
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
104巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
387
終了ページ
398
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/104/3-4/104_3-4_387/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma