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ID 30833
フルテキストURL
著者
Tsutsui, Ken Okayama University
Koide, Noriko Okayama University
Tomoda, Jun Okayama University
Hayashi, Hideo Okayama University
Hatase, Osamu Okayama University
Oda, Takuzo Okayama University
抄録

The precipitation reaction of bovine serum albumin coupled with p-azophenylleucine with homologous antibody was inhibited by several structurally related haptens. The isobutyl group substituent on alpha-carbon atom of the leucine residue contributed more than -5.8 Kcal/mol to the free energy of binding. This value was consistent with the free energy change expected from the transfer of n-butane from an aqueous environment to liquid n-butane. The observed contribution was explained, in terms of the hydrophobic interaction of the isobutyl group with the antigen binding site of the antibody molecule. These results were also compared with other hapten-antibody systems.

発行日
1977-10
出版物タイトル
Acta Medica Okayama
31巻
5号
出版者
Okayama University Medical School
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Amo Type
Article
Submission Path
amo/vol31/iss5/2