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ID 14090
Eprint ID
14090
フルテキストURL
Thumnail 106_527.pdf 6.79 MB
タイトル(別表記)
Studies on the cause of intractable asthma using animal model Part 2. Immunoglobulin G, chemical mediators and cell reactions in BALF and peripheral blood of chronic asthma model
著者
菅野 尚 岡山大学医学部第二内科学教室
抄録
To clarify the mechanism of intractable asthma, we examined the cellular content and chemical mediators in BALF and peripheral blood of a chronic asthma model which we had already established by inhalation of ascaris suum antigen. The serum levels of antigen specific IgG antibody on the eighth day were signicantly higher than those before inhalation. The serum levels of antigen specific IgG(1) antibody increased on the eighth day compared with levels before inhalation. The serum levels of antigen specific IgG(2) antibody as a blocking antibody increased and immediat asthmatic response (IAR) gradually improved until the fourth day. The number of eosinophils after eight days of inhalation was decrease in peripheral blood but was significantly increased in BAL and lung tissue. The serum levels of LTC(4) after eight days of inhalation decreased significanlty compared to those after one day of inhalation. LTB4 concentration in BAL after eight days of inhalation were significanlty lower than those after one day of inhalation. Histamine concentrations were increased in BAL in both the IAR and dual asthmatic response (DAR) animal model. These data suggest that intractable asthma was induced by many kinds of chemical mediators produced by inflammatory cells including eosinophils, mast cell-basophils, neutrophils and lymphocytes.
キーワード
chronic asthma
guinea pig
IgG subclass antibodies
leukotrienes
histamine
備考
原著
発行日
1994
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
106巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
527
終了ページ
537
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/106/5-6/106_5-6_527/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
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言語
Japanese
OAI-PMH Set
岡山大学
著作権者
Copyright© 岡山医学会
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publisher
査読
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Sort Key
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Eprints Journal Name
joma