start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=1
article-no=
start-page=103
end-page=106
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=20060315
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Synthesis of Novel Temperature-responsive Polymer Gel of Poly(aspartic acid)s
kn-title=ポリアスパラギン酸系温度応答性ゲルの創製
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Recently, thermo-responsive polymer gels have been studied in various research fields such as drug delivery system. One of represetative thermo-responsive polymer gels is poly(N-isopropylacrylamide) gel (PNIPAAm) that has a rapid and reversible volume phase transition. However, PNIPAAm is not biodegradable, resulting in limitation of its use in medical fields. Novel thermo-responsive polymer gel was prepared by closslinking of isopropylamine modified poly(succinimide) (IPA-PSI) (Poly[α,β -(DL-aspartate isopropyl amide)-co-(succinimide)]) with hexamethylenediamine. Because of peptide bonds in backbone, therefore, it is expected to possess biodegradability and biocompatibility. These gels changed their volume in response to change of environment such as temperature, pH and concentration of salt in water. Crosslinkage density and substitution degree of IPA-PSI affected volume phase transition bahavior of the gel.
en-copyright=
kn-copyright=

en-aut-name=UeharaHiroki
en-aut-sei=Uehara
en-aut-mei=Hiroki
kn-aut-name=上原広樹
kn-aut-sei=上原
kn-aut-mei=広樹
aut-affil-num=1
ORCID=

en-aut-name=TanimotoFumiaki
en-aut-sei=Tanimoto
en-aut-mei=Fumiaki
kn-aut-name=谷元史明
kn-aut-sei=谷元
kn-aut-mei=史明
aut-affil-num=2
ORCID=

en-aut-name=KitamuraYoshiro
en-aut-sei=Kitamura
en-aut-mei=Yoshiro
kn-aut-name=北村吉朗
kn-aut-sei=北村
kn-aut-mei=吉朗
aut-affil-num=3
ORCID=

en-aut-name=YoshizawaHidekazu
en-aut-sei=Yoshizawa
en-aut-mei=Hidekazu
kn-aut-name=吉澤秀和
kn-aut-sei=吉澤
kn-aut-mei=秀和
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学
en-keyword=Thermo-responsive polymer gel
kn-keyword=Thermo-responsive polymer gel
en-keyword=Biodegradable polymer
kn-keyword=Biodegradable polymer
en-keyword=Poly(aspartic acid)
kn-keyword=Poly(aspartic acid)
en-keyword=Lower Critical Solution Temperature(LCST)
kn-keyword=Lower Critical Solution Temperature(LCST)
en-keyword=Drug delivery system(DDS)
kn-keyword=Drug delivery system(DDS)
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ポリアスパラギン酸を基盤とした感温性高分子の合成と材料調製プロセスへの応用に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TanimotoFumiaki
en-aut-sei=Tanimoto
en-aut-mei=Fumiaki
kn-aut-name=谷元史明
kn-aut-sei=谷元
kn-aut-mei=史明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END