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ID 11444
Eprint ID
11444
フルテキストURL
タイトル(別表記)
Synthesis of Novel Temperature-responsive Polymer Gel of Poly(aspartic acid)s
著者
上原 広樹 岡山大学
谷元 史明 岡山大学
北村 吉朗 岡山大学
吉澤 秀和 岡山大学
抄録
Recently, thermo-responsive polymer gels have been studied in various research fields such as drug delivery system. One of represetative thermo-responsive polymer gels is poly(N-isopropylacrylamide) gel (PNIPAAm) that has a rapid and reversible volume phase transition. However, PNIPAAm is not biodegradable, resulting in limitation of its use in medical fields. Novel thermo-responsive polymer gel was prepared by closslinking of isopropylamine modified poly(succinimide) (IPA-PSI) (Poly[α,β -(DL-aspartate isopropyl amide)-co-(succinimide)]) with hexamethylenediamine. Because of peptide bonds in backbone, therefore, it is expected to possess biodegradability and biocompatibility. These gels changed their volume in response to change of environment such as temperature, pH and concentration of salt in water. Crosslinkage density and substitution degree of IPA-PSI affected volume phase transition bahavior of the gel.
キーワード
Thermo-responsive polymer gel
Biodegradable polymer
Poly(aspartic acid)
Lower Critical Solution Temperature(LCST)
Drug delivery system(DDS)
発行日
2006-03-15
出版物タイトル
岡山大学環境理工学部研究報告
出版物タイトル(別表記)
Journal of the Faculty of Environmental Science and Technology, Okayama University
11巻
1号
出版者
岡山大学環境理工学部
出版者(別表記)
Faculty of Environmental Science and Technology, Okayama University
開始ページ
103
終了ページ
106
ISSN
1341-9099
NCID
AN10529213
資料タイプ
紀要論文
関連URL
http://www.okayama-u.ac.jp/user/est/homeJapan.html
言語
Japanese
OAI-PMH Set
岡山大学
論文のバージョン
publisher
査読
無し
Sort Key
16
Eprints Journal Name
fest