著者 谷元 史明|
発行日 2010-03-25
出版物タイトル
資料タイプ 学位論文
JaLCDOI 10.18926/fest/11444
タイトル(別表記) Synthesis of Novel Temperature-responsive Polymer Gel of Poly(aspartic acid)s
フルテキストURL 011_103_106.pdf
著者 上原 広樹| 谷元 史明| 北村 吉朗| 吉澤 秀和|
抄録 Recently, thermo-responsive polymer gels have been studied in various research fields such as drug delivery system. One of represetative thermo-responsive polymer gels is poly(N-isopropylacrylamide) gel (PNIPAAm) that has a rapid and reversible volume phase transition. However, PNIPAAm is not biodegradable, resulting in limitation of its use in medical fields. Novel thermo-responsive polymer gel was prepared by closslinking of isopropylamine modified poly(succinimide) (IPA-PSI) (Poly[α,β -(DL-aspartate isopropyl amide)-co-(succinimide)]) with hexamethylenediamine. Because of peptide bonds in backbone, therefore, it is expected to possess biodegradability and biocompatibility. These gels changed their volume in response to change of environment such as temperature, pH and concentration of salt in water. Crosslinkage density and substitution degree of IPA-PSI affected volume phase transition bahavior of the gel.
キーワード Thermo-responsive polymer gel Biodegradable polymer Poly(aspartic acid) Lower Critical Solution Temperature(LCST) Drug delivery system(DDS)
出版物タイトル 岡山大学環境理工学部研究報告
発行日 2006-03-15
11巻
1号
開始ページ 103
終了ページ 106
ISSN 1341-9099
言語 Japanese
論文のバージョン publisher
NAID 120002313620