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ID 57483
フルテキストURL
著者
Yamamoto, Haruchika Department of General Thoracic Surgery and Breast and Endocrinological SurgeryOkayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Sugimoto, Seiichiro Department of General Thoracic SurgeryOkayama University Hospital 科研費研究者番号
Tanaka, Shin Department of General Thoracic Surgery and Breast and Endocrinological SurgeryOkayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Kurosaki, Takeshi Department of Organ Transplant CenterOkayama University Hospital
Otani, Shinji Department of Organ Transplant CenterOkayama University Hospital
Yamane, Masaomi Department of General Thoracic Surgery and Breast and Endocrinological SurgeryOkayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Taira, Naruto Department of Breast and Endocrinological SurgeryOkayama University Hospital
Oto, Takahiro Department of Organ Transplant CenterOkayama University Hospital
Toyooka, Shinichi Department of General Thoracic Surgery and Breast and Endocrinological SurgeryOkayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences 科研費研究者番号
抄録
PURPOSE:
Glucocorticoids are used to prevent chronic lung allograft dysfunction (CLAD) after lung transplantation (LT). Our study was aimed at assessing the association between the glucocorticoid-induced transcript 1 gene (GLCCI1) variant, which modulates glucocorticoid sensitivity, and the postoperative lung function and development of CLAD after LT.
METHODS:
A total of 71 recipients of LT were genotyped for the GLCCI1 variant (rs37972) and divided into three groups: the homozygous mutant allele (TT) group, the heterozygous mutant allele (CT) group, and the wild-type allele (CC) group. The results of pulmonary function tests were compared with the postoperative baseline values.
RESULTS:
The total lung capacity (TLC) in the TT group was significantly lower than that in the CC group at 3 years after LT (P = 0.029). In the recipients of cadaveric LT, the TLC and forced expiratory volume in 1 s in the TT group were significantly lower than those in the CC groups, resulting in a significant worse CLAD-free survival at 3 years after LT (P = 0.016).
CONCLUSION:
The GLCCI1 variant was associated with a significant decrease of the TLC at 3 years after LT and the development of CLAD at 3 years, especially in patients undergoing cadaveric LT.
キーワード
Chronic lung allograft dysfunction
Glucocorticoid
Lung transplantation
Single-nucleotide polymorphism
Total lung capacity
備考
This fulltext will be available in Dec 2017
発行日
2018-09-18
出版物タイトル
Surgery Today
49巻
3号
出版者
Springer
開始ページ
268
終了ページ
274
ISSN
09411291
NCID
AA10824685
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
論文のバージョン
author
PubMed ID
DOI
Web of Sience KeyUT
関連URL
isVersionOf https://doi.org/10.1007/s00595-018-1717-9
ライセンス
https://creativecommons.org/licenses/by-nc-nd/4.0/
Citation
Yamamoto, H., Sugimoto, S., Tanaka, S. et al. Surg Today (2019) 49: 268. https://doi.org/10.1007/s00595-018-1717-9
助成機関名
日本学術振興会
助成番号
15K10256