‰ªŽRˆãŠw‰ï Acta Medica Okayama 0030-1558 95 9-10 1983 “ï’®—cŽ™ŒP—ûŽ{�Ý‚É‚¨‚¯‚é—cŽ™“ï’®‚ÌŒ´ˆö 891 896 EN Yoshio Ogura Yu Masuda Keiko Nishioka Akiko Fujimoto Seiko Akagi Akira Fujita Tomoko Suganami Kiyoshi Matsubara Noriaki Matsumoto Hideyasu Aoyama Katsuichiro Ohsaki Buntaro Ohmori Tadashi Kinumaki Shoichiro Fukuda In 1969, Okayama Kanariya Gakuen was established as the first auditory training nursery for hard-of-hearing preschool children in Japan. From April, 1969 through March, 1980, 541 among the 1,400 children consulted there, were diagnosed as having bilateral sensorineural hearing impairment. The etiology of the impairments were classified as congenital, prenatal, perinatal or acquired. Seventy-three of the 541 cases (13.5%) were of genetic etiology. Their parents and/or brothers were diagnosed as having sensorineural hearing impairment during childhood, too. Ninety cases (16.6%) were due to maternal or prenatal disorders. Twenty-two of these cases were affected by maternal rubella. Two hundred nineteen cases (40.5%) suffered from perinatal disorders. It was suggested that anoxia was an important factor causing hearing impairment. One hundred forty-seven cases (27.2%) were due to acquired diseases which might cause hearing impairment. No abnormalities in family or past history were found in 182 cases (33.6%). This study seemed to have an advantage in that the subjects were relatively young and, therefore, detailed and reliable historys could be taken. The etiology of many other cases, however, still remains unknown even though they apparently had abnormalities in family and/or past historys. No potential conflict of interest relevant to this article was reported.

‰ªŽRˆãŠw‰ï Acta Medica Okayama 0030-1558 91 3-4 1979 “ªèò•”ˆ«�«ƒŠƒ“ƒpŽî‚ÌŽ¡—à �\•úŽË�ü—Ö@‚Æ‘½�Ü•¹—pB-COP—Ö@‚Ì�¬�Ñ�\ 503 509 EN Ryusuke Saito Yoichi Endo Teruyuki Aoki Akiko Fujimoto Seiko Akagi Yu Masuda Fifteen patients with head and neck malignant lymphomas have been treated with a combination of bleomycin, cyclophosphamide, oncovin (vincristine) and prednisolone (B-COP) in combination with radiotherapy since 1975. The results are discussed and compared with those of eleven patients treated with radiotherapy alone. Complete remission and its duration in stage II E were significantly superior to those treated with radiation alone. Toxicity, chiefly leukopenia, was generally tolerable and reversible. Although the number of cases and the follow-up period are inadequate as yet, this therapeutic regimen is a promising means of increasing the duration of remission and the survival of patients with head and neck malignant lymphomas. No potential conflict of interest relevant to this article was reported.