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ID 53521
JaLCDOI
フルテキストURL
Thumnail 69_3_145.pdf 2.52 MB
著者
Ishii, Hiroko Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine
Kamikawa, Shigeshi Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine
Hirohata, Satoshi Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine
Mizutani, Akifumi Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
Abe, Koji Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
Seno, Masaharu Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
Oohashi, Toshitaka Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine
Ninomiya, Yoshifumi Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine
抄録
Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis.
キーワード
ECP
reactive oxygen species
Akt
ERK
Amo Type
Original Article
発行日
2015-06
出版物タイトル
Acta Medica Okayama
69巻
3号
出版者
Okayama University Medical School
開始ページ
145
終了ページ
153
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT