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ID 10616
Eprint ID
10616
フルテキストURL
タイトル(別表記)
一過性脳虚血後におけるT1強調MR画像の臨床的意義
著者
青江 尚美 岡山大学
抄録
To try to determine the cause of hyperintensity of T1-weighted MR images that occurred on and after day 7 following transient cerebral ischemia, dynamic changes in T1-weighted images and histology of rats subjected to 20 min of 4-vessel occlusion were observed. T1-weighted images showed no remarkable alteration on days 1 and 3, although high signal intensity in the striatal region, in which the T1 value was significantly lower than the values on days 1 and 3, was observed on day 7. High signal intensity in T1-weighted images indicates low T1 values. Histological observation revealed accumulation of microglia in the striatal region on day 7 by lectin staining. There was a tight correlation between T1 values and number of lectin-positive cells. Microglia had stout processes and hypertrophic cell bodies on day 7, resembling lipid-laden phagocytes. Sudan black B staining showed the presence of many fatty droplets in the striatal region on day 7. Furthermore, double staining with lectin and Sudan black B revealed the presence of fatty droplets in bodies of lectin-positive cells on day 7. These results suggest that hyperintensity of T1-weighted images on day 7 following transient ischemia and reperfusion indicates accumulation and phagocytic activation of microglia. T1-weighted images seem to represent the progression of non-reversible tissue injury after transient ischemia and reperfusion.
キーワード
Cerebral ischemia
Cardiopulmonary resuscitation
Magnetic resonance imaging
T1-weighted images
Basal ganglia
Microglia
備考
http://dx.doi.org/10.1016/j.jns.2005.10.013
発行日
2006-03-24
出版物タイトル
資料タイプ
学位論文
学位授与番号
乙第4089号
学位授与年月日
2006-03-24
学位・専攻分野
博士(医学)
授与大学
岡山大学
オフィシャル URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16386758&dopt=Abstract
言語
Japanese
論文のバージョン
none
査読
不明