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ID 17475
Eprint ID
17475
フルテキストURL
Thumnail 90_1297.pdf 1.56 MB
タイトル(別表記)
Participation of superoxide generating system, superoxide dismutase and vitamin E in the radiation hazards
著者
青野 要 岡山大学医学部附属病院中央放射線部
山本 道夫 岡山大学医学部放射線医学教室
飯田 荘介 岡山大学医学部放射線医学教室
内海 耕慥 岡山大学医学部癌源研究所生化学部門
抄録
In relation to the mechanism by which hemolysis was induced in radiated human erythrocytes in vitro, several inducements of membrane lipid peroxidation and protective effects of V.E and SOD were investigated. Results obtained were as follows: (1) K(+)-release from erythrocytes was accelerated by radiation prior to hemolysis. These accelerated hemolysis and K(+)-release were protected remarkably by V.E and evidently by SOD. (2) Mitochondrial Fe(2+) induced and Fe(3+)-O(2) generating system -ADP induced lipid peroxidation, and microsomal O(2) generating system -induced lipid peroxidation were also protected by V.E and SOD. (3) Radiation of X-ray or (60)Co γ-ray accelerated lipid peroxidation of liver homogenate, microsome and liposome. Some of these accelerated lipid peroxidations were protected effectively by V.E and SOD. These results suggest that O(2) and/or OH. generation by radiation induces of membrane lipid peroxidation, which leads deterioration of membrane resulting in the change of ion permeability and then hemolysis.
発行日
1978-10-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
90巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1297
終了ページ
1308
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/90/9-10/90_9-10_1297/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma