このエントリーをはてなブックマークに追加
ID 15941
Eprint ID
15941
フルテキストURL
Thumnail 99_667.pdf 299 KB
タイトル(別表記)
A study on the galactosyltransferase activity of human gastric mucosa. Part 2. Gastric mucosal UDP galactosyltransferase activity of gastric ulcer patients and normal subjects.
著者
香川 俊介 岡山大学第一内科学教室
抄録
Biopsied specimens of gastric mucosa of normal subjects and patients with gastric ulcer were obtained under routine gastrofiberscopy. UDP-galactosyltransferase activity was measured with the use of ovomucoid as a substrate. In endoscopically normal subjects, UDP-galactosyltransferase activity of the fundic gland area was significantly (p<0.01) higher than that of the pyloric gland area. In ulcer patients without anti-ulcer treatment, UDP-galactosyltransferase activity was elevated in the mucosa surrounding the ulcer at the healing stage and red scarring stage as compared with the corresponding area of non-ulcer individuals. However, under administration of an H(2)-blocker, the change in UDP-galactosyltransferase activity was not observed. These observations may suggest that (1) increased glycoprotein synthses may be a physiological response of the gastric mucosa to the ulcer and may promote ulcer healing, and that (2) the process of the H(2)-blocker induced ulcer healing may not be associated with the apparent increase in glycoprotein synthesis.
キーワード
gastric ulcer
mucosal glycoprtein
UDP-galactosyltransferase
gastric mucosal atrophy
H(2) blocker
発行日
1987-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
99巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
667
終了ページ
672
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/99/5-6/99_5-6_667/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma