JaLCDOI 10.18926/21145
タイトル(別表記) Pulmonary lesions in rheumatoid arthritis-survey of chest radiographs in patients admitted with rheumatoid arthritis during last ten years
フルテキストURL pitsr_051_001_015.pdf
著者 谷崎 勝朗| 小田 康広| 田中 淳太郎| 駒越 春樹| 高杉 潔| 森永 寛| 原田 寛| 木村 郁郎|
抄録 Chest radiographs were examined in 147 patients with rheumatoid arthritis who were admitted at the Department ofInternal Medicine, Okayama University, Misasa Medical Branch during last ten years. The results were as follows. 1) Diffuse micronodular shadow on chest radiographs was shown in eighty nine out of 147 cases (60.5%), although the incidence of micronodular shadow was 47.3% in the other types except type 1, demonstrating the shadow limitted in the part of lower lung fields. The incidence in type 2 and 3, revealing micronodular shadow distributed over lung fields, was 22.4%. 2) The incidence of micronodular shadow was more frequently found in females than in males. The results obtained here was different from those previously reported. 3) The cases with type 2 and 3 tended to demonstrate a long duration of the desease, acceleration of ESR, positive rheumatoid factors, and elevation of serum γ-globulin and IgG levels, compared with the other types and cases without radiological findings. 4) Pulmonary lesions induced by treatment of gold or penicillamine were not recognized, except one suspected case with gold therapy.
出版物タイトル 岡山大学温泉研究所報告
発行日 1981-03-25
51巻
開始ページ 1
終了ページ 15
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310957
JaLCDOI 10.18926/21135
タイトル(別表記) Studies on Rat Peritoneal Mast Cells 2. Effect of BSA on Ca(2+) Uptake of Mast Cells
フルテキストURL pitsr_052_029_032.pdf
著者 谷崎 勝朗| 田中 淳太郎| 駒越 春樹| 森永 寛| 岸本 卓巳| 木村 郁郎| Townley Robert G.|
抄録 To examine the effect of BSA on the cell surface of mast cells, the (45)Ca influx was observed in mast cells from actively sensitized rats and also in cells passively sensitized with IgE-containing serum before or after purification by BSA. The mast cells from actively sensitized rats showed a marked increase in the (45)Ca uptake with stimulation by ovalbumin. The value of (45)Ca uptake by the cells was 1495 ± 104 cpm / 10(5) cells. The uptake of (45)Ca by mast cells passively sensitized before or after separation through BSA was also increased in response to ovalbumin, although the degree of 45Ca uptake by the latter showed marked variation. These results may suggest that BSA affects mast cell surface when the cells are sensitized after separation by BSA.
出版物タイトル 岡山大学温泉研究所報告
発行日 1982-03-25
52巻
開始ページ 29
終了ページ 32
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311041
JaLCDOI 10.18926/21134
タイトル(別表記) Studies on Rat Peritoneal Mast Cells 1. Purification of Mast Cells From Rat Peritoneal Cavity
フルテキストURL pitsr_052_023_028.pdf
著者 谷崎 勝朗| 田中 淳太郎| 駒越 春樹| 森永 寛| 岸本 卓巳| 木村 郁郎| Townley Robert G.|
抄録 To get a high recovery rate of mast cells from the rat peritoneal cavity, a new modified method was discussed using BSA density gradient. Three procedures, peritoneal lavage, washing of peritoneal cells and purification by BSA, were tested in this study, and the numbers of total cells and mast cells in each procedure were calculated. The recovery rate was the highest in BSA density gradient purification of the cells washed once with low speed centrifugation. The recovery rate was 73.7% and the number of mast cells taken from one rat was approximately 1.5×10(6). The purity of the cells with this procedure was 95.0% (range from 93.0 to 96.0%).
出版物タイトル 岡山大学温泉研究所報告
発行日 1982-03-25
52巻
開始ページ 23
終了ページ 28
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310940
JaLCDOI 10.18926/21133
タイトル(別表記) Effect of Hot-Air Room Treatment on Peripheral Leucocytes in Guinea Pigs 2. Effect of 30 Min. Hot-Air Room Treatment for 22 Days on Leucocytes Count
フルテキストURL pitsr_052_013_022.pdf
著者 谷崎 勝朗| 田中 淳太郎| 駒越 春樹| 小田 康広| 西村 佳子|
抄録 Numerical changes of peripheral leucocytes after a hot-air room treatment was observed in guinea pigs during the 22 days' successive treatment. The results were as follows. 1. Number of various leucocytes was generally decreased after the hot-air room treatment, followed by recovery to the value before treatments during 22 days' observations. 2. Numbers of total leucocytes, lymphocytes and eosinophils, which were decreased after the treatment, gradually recovered to the value before treatments during the daily hot-air room treatment. On the other hand, the recovery of neutrophils or monocytes to the count before treatment was more rapidly. The value in numerical changes of neutrophils became smaller as the hot-air room treatments were performed for many days. 3. Numerical changes of basophils and Kurloff cells did not show any definite tendency after the hot-air room treatment. 4. Numbers of total leucocytes, neutrophils, lymphocytes and eosinophils were increased and monocyte count was slightly decreased after the 22days hot-air room treatment. No change was observed in the counts of basophils and Kurloff cells.
出版物タイトル 岡山大学温泉研究所報告
発行日 1982-03-25
52巻
開始ページ 13
終了ページ 22
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310934
JaLCDOI 10.18926/21132
タイトル(別表記) Effect of Hot-Air Room Treatment on Peripheral Leucocytes in Guinea Pigs 1. Effect of Single 30 Min. Hot-Air Room Treatment on Leucocytes Count
フルテキストURL pitsr_052_001_011.pdf
著者 小田 康広| 西村 佳子| 駒越 春樹| 谷崎 勝朗|
抄録 Effect of hot-air room treatment on peripheral leucocytes was examined in guinea pigs by observing the numerical changes after the treatment. The results were as follows. 1. Number of totalleucocytes was decreased immediately after hot-air room treatment with a room temperature of 43℃, humidity of 75-87% and rapidly increased from 30 to 120 min after the treatment. Numerical changes of neutrophils showed a same tendency as that of total leucocytes. 2. Lymphocyte count was not changed or slightly decreased after the hot-air room treatment. 3. Number of basophils was decreased 30 min after the treatment and then increased, differing from that of eosinophils which showed a decreased tendency 120 min after the treatment. 4. Numbers of monocytes and Kurloff cells were slightly increased after the treatment.
出版物タイトル 岡山大学温泉研究所報告
発行日 1982-03-25
52巻
開始ページ 1
終了ページ 11
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311011
JaLCDOI 10.18926/21122
タイトル(別表記) Clinical problems of long-term steroid regimen for bronchial asthma, with reference to steroid-dependent cases
フルテキストURL pitsr_053_051_055.pdf
著者 周藤 真康| 駒越 春樹| 村嶋 誠| 岡田 千春| 谷崎 勝朗| 森永 寛| 塩田 雄太郎| 木村 郁郎|
抄録 Adverse side effects of steroid therapy were investigated in 32 asthmatic patients. Thirty-two patients were classified into three groups according to steroid therapy for the past five years; group 1 has been treated with continuous steroid therapy, group 2 with occasional steroid therapy and group 3 without steroid therapy. The results were as follows. 1. Group 1 showed a low level of serum cortisol at 8-9 a. m. The serum concentration of cortisol in patients with daily steroid regimen was lower as compared to that in patients with alternateday steroid therapy. 2. The daily profile of serum cortisol was low in the steroid dependent asthmatic patients, and little increase of serum cortisol level after the administration of prednisolone was shown in group 1. 3. Serum IgG and IgM levels were significantly low in steroid dependent asthmatic patients. 4. The level of serum potassium was low in group 1.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 51
終了ページ 55
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310967
JaLCDOI 10.18926/21121
タイトル(別表記) Clinical problems of long-term steroid regimen for bronchial asthma, with reference to steroid-dependent cases
フルテキストURL pitsr_053_045_049.pdf
著者 駒越 春樹| 周藤 真康| 岡田 千春| 谷崎 勝朗| 森永 寛| 貴谷 光| 合田 吉徳| 多田 慎也| 高橋 清| 木村 郁郎|
抄録 Adverse side effects of steroid therapy were investigated in 32 asthmatic patients. Thirty-two patients were classified into three groups according to steroid therapy for the past five years; group 1 has been treated with continuous steroid therapy, group 2 with occasional steroid therapy and group 3 without steroid therapy. The results were as follows. 1. Group 1 showed a low level of serum cortisol at 8-9 a. m. The serum concentration of cortisol in patients with daily steroid regimen was lower as compared to that in patients with alternateday steroid therapy. 2. The daily profile of serum cortisol was low in the steroid dependent asthmatic patients, and little increase of serum cortisol level after the administration of prednisolone was shown in group 1. 3. Serum IgG and IgM levels were significantly low in steroid dependent asthmatic patients. 4. The level of serum potassium was low in group 1.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 45
終了ページ 49
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311040
JaLCDOI 10.18926/21120
タイトル(別表記) Clinical effects of swimming training in a hot spring pool on bronchial asthma
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 村嶋 誠| 岡田 千春| 森永 寛| 小橋 秀敏| 多田 慎也| 木村 郁郎|
抄録 Five severe bronchial asthma patients with glucocorticoid therapy have had free swimming training in the hot spring pool at Misasa Medical Branch. The clinical effect of the swimming training was evaluated after 3 months' training. 1. A slight increase in pulse rate and blood pressure was observed immediately after 30 minutes, swimming, although no significant increase in the two parameters was shown 30 min. after the training. 2. No significant fall in ventilatory function tests such as % FVC, FEV(1.0)%, V(50) and V(25) was demonstrated following the swimming training in a hot spring pool. The results suggest that the free swimming training in a hot spring pool does not induce bronchoconstriction. 3. Clinical efficacy of the swimming training on bronchial asthma was evaluated according to a treatment score, an attack score and an asthmatic score. These scores were decreased during the swimming training. The results obtained in this study showed that free swimming training in a hot spring pool is one of the most suitable therapies for severe bronchial asthma patients.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 35
終了ページ 43
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 40000321171
JaLCDOI 10.18926/21119
タイトル(別表記) 好塩基球からのヒスタミン遊離に関する研究. 2. ハウスダスト抗原および抗ヒトIgEによるヒスタミン遊離
フルテキストURL pitsr_053_029_033.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 御般 政明| 森永 寛| 貴谷 光| 合田 吉徳| 多田 慎也| 木村 郁郎|
抄録 IgE-mediated release of histamine from whole blood was examined in two healthy and four asthmatic subjects by dose-dependent fashion. The significantly increased amount of histamine was released from basophils of both healthy and asthmatic subjects by a limited concentration of anti-IgE. Antigen (house dust) caused histamine release only from basophils of asthmatics who are sensitive to house dust. Basophils from one patients with asthma released no significant amount of histamine by anti-IgE.
抄録(別表記) 好塩基球からのIgE-mediated histamine releaseの機序を,健康人(2名)および気管支喘息(4例)それぞれの代表例で比較検討した. 抗ヒトIgEの添加濃度別検討では,健康人および外因性喘息例いずれも有意のヒスタミン遊離の増加をしめしたが,Max. % histamine releaseをひきおこす抗ヒトIgEの濃度は比較的限られた範囲内にある傾向がみられた. 一方内因性喘息例では,いずれの抗ヒトIgE濃度でも有意のヒスタミン遊離はみられなかった. ハウスダスト抗原の添加濃度別検討では,ハウスダストが抗原である気管支喘息症例においてdose-dependentなヒスタミン遊離が観察されたが,使用された抗原濃度の範囲ではMax. % releaseをひきおこす至適濃度は明らかでなかった.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 29
終了ページ 33
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310980
JaLCDOI 10.18926/21118
タイトル(別表記) 好塩基球からのヒスタミン遊離に関する研究. 1 自動分析装置による全血からのヒスタミン遊離の測定
フルテキストURL pitsr_053_023_028.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 御般 政明| 森永 寛| 大谷 純| 貴谷 光| 合田 吉徳| 多田 慎也| 木村 郁郎|
抄録 Histamine released from whole blood was determined by an automated fiuorometric histamine analysis system. The increased release of histamine from basophils by anti-IgE was observed in ten healthy subjects and 12 extrinsic asthma patients, while the release in 11 intrinsic asthma patients was significantly less as compared to that in healthy and extrinsic asthma subjects. House dust extract caused a significant increase in the histamine release from basophils of the extrinsic asthma patients who are sensitive to house dust. It was concluded from this study that histamine released from basophils could be easily determined by an automated analysis system and that the method is useful for the diagnosis and study of allergy.
抄録(別表記) ヒスタミン自動分析装置により,健康人10名,気管支喘息23例の全血からのヒスタミン遊離を測定した. 抗ヒトIgEを添加した際のヒスタミン遊離は,健康人および外因性気管支喘息症例では有意の増加傾向を示したが,一方内因性喘息症例では遊離増加はほとんどみられなかった. ハウスダスト抗原添加では,ハウスダストが抗原である気管支喘息症例においてのみ全血からの有意のヒスタミン遊離の増加が観察された. 以上の結果より,ヒスタミン自動分析装置による全血からの遊離ヒスタミンの測定は,気管支喘息の病態解明の1手段として極めて有用であると考えられる.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 23
終了ページ 28
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310945
JaLCDOI 10.18926/21106
タイトル(別表記) 好塩基球からのヒスタミン遊離に関する研究. 3. 抗ヒトIgE に対する好塩基球の反応性と末梢血好酸球増多
フルテキストURL pitsr_054_035_038.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 御般 政明| 森永 寛| 中川 三郎| 貴谷 光| 木村 郁郎|
抄録 Histamine release from basophils induced by anti-IgE was examined in 14 asthmatic subjects with blood eosinophilia. The subjects were divided into two groups; group I (with blood eosinophilia, positive skin test and positive RAST to house dust) and group II (with blood eosinophilia, negative skin test to various allergens and negative RAST to house dust). 1. Serum IgE levels in group I were much higher than those in group II. 2. Maximum percent histamine release induced by anti-IgE was much higher in group I than in group II. 3. Dose-response curve of anti-IgE-induced histamine release in group I showed consistent increase as anti-IgE concentrations increased. while, dose-response curve in group II was very low. These findings suggested that blood eosinophilia in group I might be elicited relating to IgE-mediated reaction. However, mechanism causing eosinophilia in group II was not clear in the present study.
抄録(別表記) 末梢血好酸球増多を示す気管支喘息14症例について,抗ヒトIgE による好塩基球からのヒスタミン遊離を検討した. ハウスダストに対する皮内反応およびRASTが陽性を示す症例群(groupI)では,血清IgE値が高く,また抗ヒトIgEによるMax. % ヒスタミン遊離も高く(50.7士5.0%),そのdoseresponse curveは抗ヒトIgE添加濃度が高くなるにつれて上昇する傾向を示した.一方種々のアレルゲンエキスに対する皮内反応が陰性で,かつRAST も陰性を示す症例群(group II)では,血清IgE値が低く,また抗ヒトIgEによるMax. % ヒスタミン遊離も低く(10.5士1.7%),そのdose-response curveは全般的に低く,抗ヒトIgE添加濃度が高いところではむしろ抑制される傾向を示した.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-03-25
54巻
開始ページ 35
終了ページ 38
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310989
JaLCDOI 10.18926/21103
タイトル(別表記) Effects of swimming training in the hot spring pool on ventilatory function in bronchial asthma
フルテキストURL pitsr_054_013_018.pdf
著者 周藤 真康| 駒越 春樹| 岡田 千春| 中郷 実雄| 谷崎 勝朗| 森永 寛|
抄録 Effect of free swimming training in the hot spring pool (30℃) on ventilatory function were observed in nine patients with intractable asthma by measuring FVC, FEV(1.0), PEFR, MMF, V(50), V(25). 1. Swimming in the hot spring pool for three months allowed the reduction of glucocorticoid used for their asthma attack. 2. Although FVC was not affected by swimming training, EEV(1.0), PEFR, MMF, V(50), V(25) which represent obstructive ventilatory function were gradually improved by swimming training. The results show that free swimming training in the hot springpool is clinically available in intractable asthma.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-03-25
54巻
開始ページ 13
終了ページ 18
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310964
JaLCDOI 10.18926/21095
タイトル(別表記) Spa therapy for patients with chronic obstructive lung disease
フルテキストURL pitsr_055_007_010.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 森永 寛| 貴谷 光| 中川 三郎| 木村 郁郎|
抄録 Histamine releasse from basophils induced by house dust and C. albicans was examined in 30 patients with bronchial asthma. House dust and C. albicans caused a significant amount of histamine release in subjects with a RAST score to corresponding allergen. A close correlation was found between house dust- and anti-IgE-induced histamine release. However, histamine release induced by C. albicans was considerably different from the release induced by anti-IgE.
抄録(別表記) ハウスダストあるいはカンジダが特異抗原である気管支喘息30例を対象に,それぞれの抗原刺激時の好塩基球からのヒスタミン遊離を,抗ヒトIgEによる遊離と比較検討した. 1. ハウスダストが原因抗原である症例の好塩基球からのヒスタミン遊離は,抗原刺激時41.8%,抗ヒトIgE刺激時40.8%であった. 2. カンジダが原因抗原である症例の好塩基球からのヒスタミン遊離は,抗原刺激時27.1%,抗ヒトIgE刺激時32.2%であった. 3. ハウスダストと抗ヒトIgEによる好塩基球からのヒスタミン遊離は,ほぼ同様の値を示した. 一方カンジダと抗ヒトIgEによるヒスタミン遊離の間には有意の 相関関係はみられなかった.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-11-30
55巻
開始ページ 7
終了ページ 10
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310939
JaLCDOI 10.18926/21094
タイトル(別表記) Spa therapy for patients with chronic obstructive lung disease
フルテキストURL pitsr_055_001_006.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 中郷 実雄| 森永 寛| 大谷 純| 木村 郁郎|
抄録 Thirty-six patients with chronic obstructive lung disease (34 cases with bronchial asthma, one case with chronic bronchiolitis and one case with pulmonary emphysema) have received spa therapy. Clinical effects of sa therapy on patients with bronchial asthma depended on patient age and asthma types classified by allergic reactions and clinical symptoms. Spa therapy was effective in the cases with ages more than 31 years and the cases with non-atopic type of bronchial asthma. Regarding asthma type classified by clinical symptoms, spa therapy was more effective in the cases with bronchiolar obstructive type and the cases with bronchospasm + hypersecretion type than in the cases with bronchospasm type of bronchial asthma.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-11-30
55巻
開始ページ 1
終了ページ 6
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311032
JaLCDOI 10.18926/21084
タイトル(別表記) Spa therapy for patients with chronic obstructive lung disease
フルテキストURL pitsr_056_023_026.pdf
著者 周藤 眞康| 駒越 春樹| 谷崎 勝朗| 森永 寛|
抄録 During last three years, 41 patients with chronic obstructive lung disease (39 cases with bronchial asthma and 2 cases with chronic bronchiolitis) received spa therapy at Department of Medicine, Okayama University Medical School, Misasa Medical Branch. 1. Twenty three (56%) out of 41 cases came from Okayama prefecture and 10 cases (24.4%) from Tottori prefecture for spa therapy. In twenty five (61.0%) out of 41 cases, their ages were over 50 years. 2. Thirty nine patients with bronchial asthma were divided into three asthma types classified by clinical symptoms : Ia ; 16 cases (41.0%), Ib; 13 cases (33.3%) and II ; 10 cases (25.7%). Pulmonary function tests for these patients showed that small airways obstruction was most remarkable in type II asthma. 3. The mean serum IgE level of all asthmatic patients (39 cases) was 653.9U/ml. In skin test by allergens, positive immediate skin reaction was shown in 18 cases (46.2%) by Candida and 12 cases (30.8%) by house dust. Specific IgE anti-bodies were found in 9 cases (23.1%) for house dust and 3 cases (7.7%) for Candida.
出版物タイトル 岡山大学温泉研究所報告
発行日 1985-03-30
56巻
開始ページ 23
終了ページ 26
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311025
JaLCDOI 10.18926/21083
タイトル(別表記) 好塩基球からのヒスタミン遊離に関する研究. 5.臨床的評価
フルテキストURL pitsr_056_017_021.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 森永 寛|
抄録 過去3年間にわたり,気管支喘息患者末梢血好塩基球からのヒスタミン遊離について,ヒスタミン自動分析装置を用いて全血法により検討を加えてきた. 1. 抗ヒトIgE によるヒスタミン遊離は,症例間で著しい差がみられた. この際血清IgE値が高値を示す症例では全般的に高度なヒスタシソ遊離がみられたが,血清IgE値が正常かまたはむしろ低値を示す症例のヒスタミン遊離は,かなり高度なものから全くみられないものまでさまざまであった. 2.ハウスダストやカンジダなどの抗原物質によるヒスタミン遊離は,特異的IgE抗体依存性であり,抗体価が上昇するにつれヒスタミン遊離は高度となる傾向がみられた. しかし,ハウスダストとカンジダによるヒスタミン遊離には若干の差がみられた. すなわち,ハウスダストと抗ヒトIgE によるヒスタミン遊離の間には密接な関連がみられたが,カンジダと抗ヒトIgEの間には全く関連がみられなかった. またカンジダによるヒスタミン遊離においては,IgE系反応以外の反応が関与する可能性が一部示唆された.
出版物タイトル 岡山大学温泉研究所報告
発行日 1985-03-30
56巻
開始ページ 17
終了ページ 21
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310985
JaLCDOI 10.18926/19710
タイトル(別表記) Study on anti-allergic action of Terfenadine
フルテキストURL 058_005_011.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 貴谷 光|
抄録 選択的H(1)受容体拮抗薬であるTerfenadineの抗アレルギー作用,特にIgE系反応によるヒスタミン,およびCa ionophore A23187による好中球からのleukotrienes遊離に対する抑制作用を,ヒト末梢血白血球を用いて検討した。1.Terfenadineは,抗ヒトIgE刺激による健康人好塩基球および特異抗原刺激による気管支喘息患者好塩基球からのヒスタミン遊離に対して,全血法でのin vitro添加実験では有意の抑制作用を示さなかった。 2.洗浄白血球法によるin vitro添加実験では,Terfenadineは特異抗原および抗ヒトIgE刺激時の気管支喘息患者好塩基球からのヒスタミン,Ca ionophore A23187刺激時のleukotriene B(4)遊離に対して有意の抑制効果を示した。3.Terfenadineの内服によるin vivoの抑制実験では,IgE系反応による健康人および気管支喘息患者好塩基球からのヒスタミン遊離に対して有意の抑制効果は見られなかったが,特異抗原による皮膚反応に対しては明らかな抑制作用が観察された。以上より,Terfenadineは,組織肥満細胞および組織へと遊走してきた好塩基球に対してはある程度の抑制作用を有しているものと考えられた。
抄録(別表記) Anti-allergic action of terfenadine, one of the H(1) receptor inhibitors, was examined by human basophil histamine release induced by anti-IgE or a specific allergen (house dust), and the release of leukotriens from leucocytes stimulated by Ca ionophore A23187. 1. Terfenadine did not inhibit the release of histamine from basophils of healthy subjects induced by anti-IgE, and also of patients with bronchial asthma induced by house dust when the in vitro examination was performed by a whole blood method. 2. Histamine release from basophils of patients with bronchial asthma was significantly inhibited when washed leucocytes was preincubated with terfenadine in vitro. The release of LT B(4) from leucocytes was also inhibited. 3. In vivo examination of inhibitory action of terfenadine showed no effect on basophil histamine release of healthy subjects by anti-IgE and of asthmatic subjects by house dust, although skin test by house dust in these subjects was inhibited 60 min after administration in vivo. These results show that terfenadine inhibits the release of chemical mediators from tissue mast cells, and basophils migrating into local allergic sites.
キーワード 夕一フェナンジン (Terfenadine) lgE系反応 (IgE-mediated reaction) ヒスタミン (histamine) 好塩基球 (basophils)
出版物タイトル 環境病態研報告
発行日 1987-08
58巻
開始ページ 5
終了ページ 11
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002309197
JaLCDOI 10.18926/19683
タイトル(別表記) Studies on anti-allergic actions of tranilast (Rizaben®)
フルテキストURL 057_042_045.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 森永 寛| 大谷 純| 木村 郁郎|
抄録 抗アレルギー剤(脱顆粒抑制剤)の1つであるtranilastの肥満細胞の遊離機序に対する抑制作用について検討を加えた。1.抗原刺激時の肥満細胞の(45)Ca uptakeおよびヒスタミン遊離に対して,tranilastは有意の抑制作用を示したが,comp.48/80刺激時にはtranilastの(45)Ca uptake,ヒスタミン遊離に対する抑制作用はほとんどみられなかった。2.phosphatidylserine添加時には,(45)Ca uptakeに対するtranilastの抑制作用は減弱傾向を示し,この傾向はヒスタミン遊離に対する作用に比べより高度であった。3.抗原および抗ヒトIgEによる好塩基球からのヒスタミン遊離に対して,tranilastは明らかな抑制作用を示さなかった。
抄録(別表記) Tlanilast is clinically used for bronchial asthma as one of the prophylactic agents for asthma attacks. In this study, anti-allergic actions of tranilast were examined in (45)Ca uptake of and histamine release from target cells of IgE after stimulation with antigen, anti-IgE and camp. 48/80. 1. (45)Ca uptake of and histamine release from rat peritoneal mast cells stimulated by antigen were significantly inhibited by preincubation of the cells with tranilast. Inhibition by tranilast of increased (45)Ca uptake of mast cells by addition of phosphatidylserine were less, although inhibition of histamine release was not so affected by addition of phosphatidylserine. No significant inhibition by tranilast of (45)Ca uptake and histamine release was not observed when the cells were stimulated by camp. 48/80. 2. Tranilast showed any inhibitory effects on basophil histamine release induced by antigen and anti-IgE.
キーワード トラニラスト (tranilast) (45)Ca取り込み ((45)Ca uptake) ヒスタミン遊離 (histamine release) 肥満細胞 (mast cell) 好塩基球 (basophils)
出版物タイトル 環境病態研報告
発行日 1986-07
57巻
開始ページ 42
終了ページ 45
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002308998
JaLCDOI 10.18926/19678
タイトル(別表記) Spa therapy for bronchial asthma. Annual changes of characteristics of asthmatics admitted during the past four years.
フルテキストURL 057_037_041.pdf
著者 谷崎 勝朗| 周藤 真康| 駒越 春樹| 森永 寛|
抄録 1982年1月から1985年12月までの4年間に三朝分院内科へ入院し,温泉療法を受けた気管支喘息45例を対象にその年次推移を検討した。1.性別:初期2年間は男性の入院症例が多い状況であったが,後期2年間では男女比はほぼ等しかった。2.年令:年次推移はみられず,その平均年令は50±2才の間にあった。3.地域分布:初期2年間は岡山県からの入院症例が多数をしめたが,後期2年間ではむしろ鳥取県からの入院症例が増加する傾向がみられた。4.入院期間:初期2年間の平均入院期間は6.7カ月,6.5カ月とかなり長くなる傾向がみられたが,後期2年間ではそれぞれ3.0カ月,1.5カ月と明らかな短縮傾向がみられた。5.臨床病型:いずれの年度においても重症化傾向の強いⅠb型,Ⅱ型が多くみられたが,各年度間には差はみられなかった。6.ステロイド剤使用状況:年度の経過とともにその使用量は減少して いく傾向が示された。
抄録(別表記) Annual changes of characteristics, sex, area (Prefecture) of patients' coming from, term of admission, clinical classification of asthma and use of glucocorticoids, were examined in 45 patients with bronchial asthma who were admitted at Misasa Hospital, Okayama University Medical School and received spa therapy during the past four years from 1982 to 1985. In the first two years from 1982 to 1983, more patients with bronchial asthma were admitted from Okayama Prefecture, and the majority of them had severe asthma attacks and were more dependent on steroid-therapy. On the other hand, in the past two years from 1984 to 1985, number of patients with bronchial asthma from Tottori Prefecture increases, and their attacks were less severe and less dependent on steroid-therapy compared to the patients admitted during the first two years. Term of admission became shorter in the past two years than in the first two years. Any differences between the first and the past two years were not shown in sex, patient age and asthma types classified by clinical symptoms.
キーワード 気管支喘息 (Bronchial asthma) 温泉療法 (spa therapy) 臨床病型 (asthma type)
出版物タイトル 環境病態研報告
発行日 1986-07
57巻
開始ページ 37
終了ページ 41
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002309135
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 中郷 実雄| 森永 寛| 大谷 純| 多田 慎也| 高橋 清| 木村 郁郎|
発行日 1984-04-30
出版物タイトル 岡山医学会雑誌
96巻
3-4号
資料タイプ 学術雑誌論文