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ID 15950
Eprint ID
15950
フルテキストURL
Thumnail 100_547.pdf 512 KB
タイトル(別表記)
Bactericidal activity of polymorphonuclear leukocytes against pathogenic bacteria and the function of B lymphocytes in critiacally ill patients
著者
赤尾 正樹 岡山大学医学部麻酔・蘇生学教室
抄録
I studied host resistance to infection in critically ill patients with nosocomial pneumonia due to gram-negative bacilli. The bactericidal activity of polymorphonuclear leukocytes (PMNs) against pathogenic bacteria was estimated by zymosan-induced and bacteria-induced chemiluminescence (CL). The function of B lymphocytes was examined by measurement of lymphocyte numbers, subpopulations, subsets, and plasma immunoglobulins. The zymosaninduced CL did not correlate significantly with the bacteria-induced CL. This finding indicates that zymosan cannot be used for the estimation of bactericidal activity of PMN against pathogenic bacteria in critically ill patients. Lymphocyte numbers were very low, and the parcentage of suppressor T lymhocytes was low, and consequently the ratio of helper to suppressor T lymphocytes was somewhat high. There was a significant negative correlation between the plasma level of IgG and the percentage of B lymphocytes (p<0.05). The bactericidal activity of PMNs and the function of B lymphocytes tended to be suppressed as the plasma level of IgG increased. From these results, I conclude that: 1. There is negative feedback between IgG and B lymphocytes. 2. Host resistance to infection is suppressed in critically ill patients, if IgG is elevated.
キーワード
重症患者
ケミルミネッサンス
好中球殺菌能
B細胞
IgG
発行日
1988
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
100巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
547
終了ページ
554
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/100/5-6/100_5-6_547/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma