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ID 16757
Eprint ID
16757
フルテキストURL
Thumnail 93_1105.pdf 1.83 MB
タイトル(別表記)
α-Guanidinoglutaric acid and other guanidino compounds in a cobalt epileptogenic focus of cat cerebral cortex
著者
赤木 正幸 岡山大学医学部脳代謝研究施設機能生化学部門
抄録
An epileptogenic cortical focus was induced by the topical application of cobalt powder to the sensori-motor cortex, then guanidino compounds in the cobalt focus were analysed by HPLC. An extraordinally high peak was observed in the epileptogenic focus 24 hours after the cobalt application. α-Guanidinoglutaric acid (GGA), which is synthesized from glutamic acid and S-methylisothiourea sulfate, was confirmed by GC/MS as a dimethylpyrimidyl derivative of GGA. An unknown substance was isolated from the cobalt focus and identified as GGA by the same GC/MS technique as in the case of an authentic sample. GGA was present in the normal cat cortex in amounts of 1n mol/g. GGA increased after cobalt application, and reached a maximum after 24 hours. The abnormal GGA recovered to the normal level about 40days after the application by which time the cobalt focus had disappeared. Other guanidino compounds, that is taurocyamine, guanidinosuccinic acid, guanidinoacetic acid, β-guanidinopropionic acid, creatinine, γ-guanidinobutyric acid, arginine, and methylguanidine, except for guanidine tended to decrease in the cobalt focus. Taurocyamine and α-guanidinobutyric acid were still decreased 40 days after the cobalt application. Spike and wave complex was induced after topical application of 0.2M GGA to the sensori-motor cortex, and a burst continued for one hour.
キーワード
コバルト焦点 (cobalt focus)
α-guanidinoglutaric acid
guanidino化合物 (guanidino compounds)
EEG
発作機序 (seizure mechanism)
発行日
1981-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
93巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1105
終了ページ
1119
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/93/11-12/93_11-12_1105/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma