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ID 54829
フルテキストURL
Thumnail 71_1_79.pdf 2.1 MB
著者
Iwasaki, Yuka Department of Pediatrics, Kochi Health Sciences Center
Nishiuchi, Rituo Department of Pediatrics, Kochi Health Sciences Center
Aoe, Michinori Division of Medical Support, cDepartment of Pediatrics, Okayama University Hospital
Takahashi, Takahide Division of Medical Support, cDepartment of Pediatrics, Okayama University Hospital
Watanabe, Hirokazu Department of Pediatrics, Kochi Health Sciences Center
Tokorotani, Chiho Department of Pediatrics, Kochi Health Sciences Center
Kikkawa, Kiyoshi Department of Pediatrics, Kochi Health Sciences Center
Shimada, Akira Department of Pediatrics, Okayama University Hospital
抄録
Acute myeloid leukemia (AML) patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) often have a poor prognosis, even after hematopoietic stem cell transplantation (HSCT). We report a case of AML with FLT3-ITD identified upon initial diagnosis, who received HSCT at complete remission after 3 consecutive chemotherapies. However, the patient relapsed when the same FLT3-ITD clone emerged, and finally died. Retrospective analysis revealed an allelic ratio of FLT3-ITD/wild type of 1.1 and 0.0096 upon initial diagnosis and before HSCT, respectively. The detection of any minimal residual FLT3-ITD clone before HSCT is useful in the treatment of AML with FLT3-ITD.
キーワード
acute myeloid leukemia
relapse
FLT3-ITD
HSCT
minimal residual disease
発行日
2017-02
出版物タイトル
Acta Medica Okayama
71巻
1号
出版者
Okayama University Medical School
開始ページ
79
終了ページ
83
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Amo Type
Case Report
Submission Path
amo/vol71/iss1/11
JaLCDOI