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ID 30723
JaLCDOI
フルテキストURL
著者
Ashizawa, Tatsuto Tokyo Medical University Hachioji Medical Center, Tokyo
Okada, Ryosuke Tokyo Medical University Hachioji Medical Center, Tokyo
Suzuki, Yoshiaki Tokyo Medical University Hachioji Medical Center, Tokyo
Takagi, Makoto Tokyo Medical University Hachioji Medical Center, Tokyo
Yamazaki, Tatsuyuki Tokyo Medical University Hachioji Medical Center, Tokyo
Sumi, Tetsuo Tokyo Medical University Hachioji Medical Center, Tokyo
Aoki, Toshiaki Tokyo Medical University Hachioji Medical Center, Tokyo
Aoki, Tatsuya Tokyo Medical University Hachioji Medical Center, Tokyo
抄録
We investigated the diagnostic significance of IL-6 for lymph node metastasis and/or hepatic metastasis from colorectal cancer in 65 patients and evaluated the contributions of 8 factors (IL-6, HGF, IL-1beta, TNF-alpha, TGF-beta1, ELAM-1, ICAM-1, VCAM-1) toward Dukes.s classification of 53 patients. We also examined IL-6 expression in tumor tissue. From the receiver operating characteristic (ROC) curve analysis, an optimal cutoff value of 5.8 pg/ml was determined to classify lymph node and/or hepatic metastasis, and that of 6.3 pg/ml was determined to classify hepatic metastasis. These values indicated sensitivities of 55.0% and 71.4%, and specifi cities of 100% and 88.6%, respectively. IL-6, HGF, and ELAM-1 were very useful for distinguishing among Dukes.s A/B group, C group, and D group. In all cases with high IL-6 values (more than 25.0 pg/ml), immunohistochemical staining was positive for IL-6 in the cytoplasm of cancer cells. IL-6 is strongly suspected to be involved in lymph node and/or hepatic metastasis by promoting it through HGF, and serum IL-6 value (pg/ml) would be useful diagnostically to estimate whether or not there is a high risk of lymph node and/or hepatic metastasis.
キーワード
IL-6
colorectal cancer
lymph node metastasis
hepatic metastasis
diagnostic signifi cance
Amo Type
Original Article
発行日
2006-12
出版物タイトル
Acta Medica Okayama
60巻
6号
出版者
Okayama University Medical School
開始ページ
325
終了ページ
330
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT