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ID 50719
フルテキストURL
著者
Bekku, Kensuke Okayama Univ, Dept Urol, Grad Sch Med Dent & Pharmaceut Sci
Saika, Takashi Okayama Univ, Dept Urol, Grad Sch Med Dent & Pharmaceut Sci
Kobayashi, Yasuyuki Okayama Univ, Dept Urol, Grad Sch Med Dent & Pharmaceut Sci
Kioshimoto, Ryo Okayama Univ, Dept Urol, Grad Sch Med Dent & Pharmaceut Sci
Kanbara, Taiki Okayama Univ, Dept Urol, Grad Sch Med Dent & Pharmaceut Sci
Nasu, Yasutomo Okayama Univ, Dept Urol, Grad Sch Med Dent & Pharmaceut Sci
Kumon, Hiromi Okayama Univ, Dept Urol, Grad Sch Med Dent & Pharmaceut Sci
抄録
The clinical impact of salvage surgery after chemotherapy on cancer survival of patients with metastatic urothelial carcinoma is controversial. We aimed to verify the clinical role of salvage surgery by analyzing the long-term outcome in patients with urothelial carcinoma treated by chemotherapy. Between 2003 and 2010 at a single institution, 31 of 47 patients (66%) with metastatic urothelial carcinoma showed objective responses (CR in 4, PR in 27) after multiple courses of cisplatin/gemcitabine/paclitaxel-based chemotherapy, and a cohort of patients with partial response (PR) were retrospectively enrolled. Twelve (10 male and 2 female, median age 64.0 years) of 27 patients with PR underwent salvage surgeries after the chemotherapy: metastatectomy of residual lesions (10 retroperitoneal lymph nodes, 2 lung), and 6 radical surgeries for primary lesions as well. Progression-free survival and overall patient survival rates were analyzed retrospectively and compared with those of patients without salvage surgery. All 12 patients achieved surgical CR. Pathological findings of metastatic lesions showed viable cancer cells in 3 patients. In univariate analysis, sole salvage surgery affected overall survival in 27 patients with PR to the chemotherapy (P = 0.0037). Progression-free survival and overall survival rates in patients with salvage surgery were better than those in 15 PR patients without the surgery (39.8 vs. 0%, and 71.6 vs. 12.1% at 3 years, P = 0.01032 and 0.01048; log-rank test). Salvage surgery for patients with residual tumor who achieve partial response to chemotherapy could have a possible impact on cancer survival.
キーワード
Chemotherapy
Metastatectomy
Metastatic urothelial carcinoma
Salvage surgery
Urothelial carcinoma
発行日
2013-02
出版物タイトル
International Journal of Clinical Oncology
18巻
1号
出版者
Springer Japan KK
開始ページ
110
終了ページ
115
ISSN
1341-9625
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1007/s10147-011-0350-z
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/50685
言語
English
論文のバージョン
author
査読
有り
DOI
Web of Sience KeyUT