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ID 56678
フルテキストURL
著者
Dutta, Sanjucta Division of Bacteriology, National, Collaborative Research Centre of Okayama University for Infectious Diseases in India
Guin, Sucharita Clinical Division, Institute of Cholera and Enteric Diseases, Collaborative Research Centre of Okayama University for Infectious Diseases in India
Ghosh, Santanu Division of Bacteriology, National, Collaborative Research Centre of Okayama University for Infectious Diseases in India
Pazhani, Gururaja P. Division of Bacteriology, National, Collaborative Research Centre of Okayama University for Infectious Diseases in India
Rajendran, Krishnan Division of Bacteriology, National, Collaborative Research Centre of Okayama University for Infectious Diseases in India
Bhattacharya, Mihir K. Clinical Division, Institute of Cholera and Enteric Diseases, Collaborative Research Centre of Okayama University for Infectious Diseases in India
Takeda, Yoshifumi National Institute of Cholera and Enteric Diseases
Nair, G. Balakrish Translational Health Science and Technology Institute
Ramamurthy, Thandavarayan Division of Bacteriology, National, Collaborative Research Centre of Okayama University for Infectious Diseases in India
抄録
BACKGROUND:  To analyse the trends in the prevalence of different pathogroups of diarrheagenic Escherichia coli (DEC) among hospitalized acute diarrheal patients.  METHODOLOGY/PRINCIPAL FINDINGS:  From the active surveillance of diarrheal disease at the Infectious Diseases Hospital, Kolkata, 3826 stool specimens collected during 2008-2011 were screened for DEC and other enteric pathogens. PCR was used in the detection of enterotoxigenic, enteropathogenic and enteroaggregative E. coli and 10 major colonization factor antigens (CFs) of enterotoxigenic E. coli. The relationship between DEC infected patient's age group and clinical symptoms were also investigated. Multiplex PCR assay showed that the prevalence of EAEC was most common (5.7%) followed by ETEC (4.2%) and EPEC (1.8%). In diarrheal children >2 year of age, EAEC and EPEC were detected significantly (p = 0.000 and 0.007, respectively). In children >2 to 5 and >5 to 14 years, ETEC was significantly associated with diarrhea (p = 0.000 each). EAEC was significantly associated with diarrheal patients with age groups >14 to 30 and >30 to 50 years (p = 0.001, and p = 0.009, respectively). Clinical symptoms such as vomiting, abdominal pain, watery diarrhea, were recorded in patients infected with ETEC. Dehydration status was severe among patients infected by ST-ETEC (19%) and EPEC (15%). CS6 was frequently detected (37%) among ETEC.  CONCLUSIONS/SIGNIFICANCE:  Hospital based surveillance reviled that specific pathogroups of DEC are important to certain age groups and among ETEC, CS6 was predominant.
備考
This work was supported in part by the Japan Initiative for Global Research Network on Infectious Diseases, Ministry of Education, Culture, Sports, Science and Technology, Japan and from intramural grants of the Indian Council of Medical Research, New Delhi, India.
発行日
2013-02-14
出版物タイトル
PLOS One
8巻
2号
出版者
Public Library of Science
開始ページ
e56068
ISSN
19326203
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
論文のバージョン
publisher
PubMed ID
DOI
Web of Sience KeyUT
関連URL
isVersionOf https://doi.org/10.1371/journal.pone.0056068
プロジェクト
インド感染症共同研究