JaLCDOI 10.18926/AMO/32030
フルテキストURL fulltext.pdf
著者 Bagum, Mossa Arujuma| Miyamoto, Osamu| Masada, Tetsuya| Nagahata, Shun-ichirou| Toyoshima, Tetsuhiko|
抄録 <p>The implication of low affinity nerve growth factor receptor (p75NGFR), which is believed to play a pro-apoptotic role, in delayed neuronal death (DND) after ischemia in the gerbil hippocampus was investigated. Immunohistochemistry and Western blot analysis revealed that the presence of p75 NGFR immunoreactivity (IR) was negligible in the hippocampus of the sham control gerbil but appeared clearly in CA1 neurons 3 and 4 days after 5-min transient ischemia. Terminal deoxynucleotidyl transferase-mediated UTP nick end labeling (TUNEL) </p> <p>positive nuclei appeared when the level of p75NGFR IR increased. Furthermore, almost all TUNEL-positive CA1 neurons also costained for p75NGFR. These results suggest that p75NGFR contributes to DND after ischemia by an apoptotic mechanism.</p>
キーワード p75NGFR apoptosis delayed neuronal death ischemia gerbil
Amo Type Article
発行日 2001-02
出版物タイトル Acta Medica Okayama
55巻
1号
出版者 Okayama University Medical School
開始ページ 19
終了ページ 24
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11246973
Web of Sience KeyUT 000167249900003