JaLCDOI 10.18926/AMO/31967
フルテキストURL fulltext.pdf
著者 Kurtoglu, Zeliha| Ozturk, Ahmet Hakan| Bagdatoglu, Celal| Polat, Gurbuz| Aktekin, Mustafa| Uzmansel, Deniz| Camdeviren, Handan| Bagdatoglu, Ozlen| Sargon, Mustafa|
抄録 <p>In this study, we evaluated the effects of trapidil on crush injury by monitoring nitric oxide, malondialdehyde and transforming growth factor-Beta2 levels and by transmission electron microscopy in the rat sciatic nerve. The sciatic nerve was compressed for 20 sec by using a jewelers forceps. Trapidil treatment groups were administrated a single dose of trapidil (8 mg/kg) intraperitoneally just after the injury. The crush and crush + trapidil treatment groups were evaluated on the 2nd, 7th, 15th, 30th and 45th days of the post-crush period. On the 7th and 15th days, damage in thin and thick myelinated axons, endoneural edema and mitochondrial swelling were less severe in the trapidil group histopathologically. These findings supported the idea that trapidil prevented cell damage and edema at the injury site. Day/group interaction with regard to serum nitric oxide, malondialdehyde and transforming growth factor-Beta2 levels did not show significant changes.</p>
キーワード trapidil crush injury peripheral nerve electron microscopy nitric oxide
Amo Type Article
発行日 2005-04
出版物タイトル Acta Medica Okayama
59巻
2号
出版者 Okayama University Medical School
開始ページ 37
終了ページ 44
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 16049553
Web of Sience KeyUT 000228590000001