フルテキストURL Mod_Rheumatol_26_5_730.pdf
著者 Sada, Ken-ei| Harigai, Masayoshi| Amano, Koichi| Atsumi, Tatsuya| Fujimoto, Shouichi| Yuzawa, Yukio| Takasaki, Yoshinari| Banno, Shogo| Sugihara, Takahiko| Kobayashi, Masaki| Usui, Joichi| Yamagata, Kunihiro| Homma, Sakae| Dobashi, Hiroaki| Tsuboi, Naotake| Ishizu, Akihiro| Sugiyama, Hitoshi| Okada, Yasunori| Arimura, Yoshihiro| Matsuo, Seiichi| Makino, Hirofumi|
キーワード Antineutrophil cytoplasmic antibody-associated vasculitis Eosinophilic granulomatosis with polyangiitis Granulomatosis with polyangiitis Inception cohort Microscopic polyangiitis
備考 This is an Accepted Manuscript of an article published by Taylor & Francis Group
発行日 2016-03-11
出版物タイトル Modern Rheumatology
26巻
5号
出版者 Taylor & Francis
開始ページ 730
終了ページ 737
ISSN 1439-7595
NCID AA1157187X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 26873424
DOI 10.3109/14397595.2016.1140274
Web of Sience KeyUT 000393120600018
関連URL https://doi.org/10.3109/14397595.2016.1140274
JaLCDOI 10.18926/AMO/31702
フルテキストURL fulltext.pdf
著者 Yoshinouchi, Takeo| Ohtsuki, Yuji| Fujita, Jiro| Sugiura, Yoshiki| Banno, Shogo| Sato, Shigeki| Ueda, Ryuzo|
抄録 <p>Pathologic features of Mycoplasma pneumoniae infection (M. pneumonia) are generally non-specific, and the literature regarding the pathologic features of M. pneumonia with intraalveolar exudates is limited. Clinical and histopathological studies were performed in 3 patients with M. pneumonia which did not respond to erythromycin and minocycline, but all rapidly recovered after corticosteroid therapy. In pathologic findings, we observed intraalveolar exudates and focal organization in M. pneumonia, and its intraalveolar lesions were compared between M. pneumonia and bronchiolitis obliterans organizing pneumonia containing fibrin (BOOP). Immunohistochemical studies were performed using the streptavidin biotin peroxidase complex method with anti-alpha-smooth muscle actin antibody and anti-pancytokeratin AE1/AE3 antibody. In pathologic findings, more fibrin deposits in intaalveolar lesions were observed in M. pneumonia than in BOOP. In intaalveolar lesions of M. pneumonia, a larger amount of nuclear debris, more neutrophils, and more erythrocytes were noted. Myofibroblasts were observed in the organization of BOOP, while in the intaalveolar lesions of M. pneumonia, myofibroblasts were not observed. These results suggest that M. pneumonia with intraalveolar exudates responds well to corticosteroid and its intraalveolar lesions apparently differed from those in BOOP.</p>
キーワード exudate fibrin Mycoplasma pneumonia organizing pneumonia steroid therapy
Amo Type Article
発行日 2002-04
出版物タイトル Acta Medica Okayama
56巻
2号
出版者 Okayama University Medical School
開始ページ 111
終了ページ 116
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 12002617
Web of Sience KeyUT 000175176900008