JaLCDOI 10.18926/AMO/30446
フルテキストURL fulltext.pdf
著者 Tanaka, Michio| Inatsuchi, Shuji| Terasaki, Teiichi| Funaki, Jun| Bandou, Tsuyosi| Shimada, Kazuhiko| Wakabayashi, Hiroyuki| Kubota, Yoshiki| Watanabe, Akiharu|
抄録 <p>Clinical studies show that patients with liver cirrhosis associated with portal hypertension have a high incidence of duodenal ulcer and duodenitis. However, little information is available concerning pathophysiological process of such duodenal diseases in liver cirrhosis. Hemodynamics of the duodenal mucosa was studied in cirrhotics with esophageal varices (68 cases) and in noncirrhotics with non-ulcer dyspepsia (37 cases) as well. In each group, hemoglobin concentration in the peripheral venous blood was measured, and mucosal hemodynamics was examined in 4 regions of the duodenum by endoscopic reflectance spectrophotometer. No significant intergroup difference was noted in the mean age or sex ratio. Hemoglobin concentration in the peripheral venous blood was significantly lower (p less than 0.01) in the cirrhotics. There were no significant intergroup differences in duodenal mucosal blood volume. However, the cirrhotics showed significantly lower oxygen saturation of hemoglobin in all regions of the duodenum (p less than 0.01). These results show that the cirrhotics with esophageal varices had relative increase in blood volume and decrease in oxygen saturation of hemoglobin in the duodenal mucosa. Such microcirculatory disturbances seem to predispose liver cirrhosis patients to duodenal injury.</p>
キーワード liver cirrhosis portal hypertension duodenal mucosa reflectance spectrophotometry duodenoscopy
Amo Type Article
発行日 1990-10
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 273
終了ページ 277
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2260499
Web of Science KeyUT A1990EG00700007