このエントリーをはてなブックマークに追加
ID 50972
フルテキストURL
著者
Danura, Tetsuya Department of Anesthesiology and Resuscitology, Okayama University Medical School
Takeda, Yoshimasa Department of Anesthesiology and Resuscitology, Okayama University Medical School
Shiraishi, Kensuke Department of Anesthesiology, Maizuru Kyosai Hospital
Naito, Hiromichi Department of Anesthesiology and Resuscitology, Okayama University Medical School
Mizoue, Ryoichi Department of Anesthesiology and Resuscitology, Okayama University Medical School
Sato, Sachiko Department of Anesthesiology and Resuscitology, Okayama University Medical School
Morita, Kiyoshi Department of Anesthesiology and Resuscitology, Okayama University Medical School
抄録
BACKGROUND: Neuroprotective effects of esmolol in laboratory and clinical settings have been reported. The present study was designed to quantitatively evaluate the neuroprotective effects of esmolol using logistic regression curves and extracellular potentials. MATERIALS AND METHODS: In 42 gerbils, bilateral occlusion of common carotid arteries was performed for 3, 5, or 7 minutes (n=7 in each group). In treated animals, esmolol (200 µg/kg/min) was administered for 90 minutes, 30 minutes before the onset of ischemia. Direct current potentials were measured in the bilateral CA1 regions, in which histologic evaluation was performed 5 days later. Relations of neuronal damage with ischemic duration and duration of ischemic depolarization were determined using logistic regression curves. RESULTS: There was no significant difference in onset time between the 2 groups (the control group vs. the esmolol group: 1.65±0.46 vs. 1.68±0.45 min, P=0.76), and significant differences in durations of ischemic depolarization were not observed with any ischemic duration. However, logistic regression curves indicated that esmolol has a neuroprotective effect from 2.95 to 7.66 minutes of ischemic depolarization (P<0.05), and esmolol prolonged the duration of ischemic depolarization causing 50% neuronal damage from 4.97 to 6.34 minutes (P<0.05). Logistic regression curves also indicated that esmolol has a neuroprotective effect from 3.77 to 7.74 minutes of ischemic duration (P<0.05), and esmolol prolonged the ischemic duration causing 50% neuronal damage from 4.26 to 4.91 minutes (P<0.05).
キーワード
esmolol
[beta]-adrenoceptor
ischemic depolarization
neuroprotective effect
brain ischemia.
発行日
2013-07
出版物タイトル
Journal of Neurosurgical Anesthesiology
25巻
3号
開始ページ
292
終了ページ
298
ISSN
0898-4921
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1097/ANA.0b013e31827fe3b1
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/50678
言語
English
論文のバージョン
author
査読
有り
DOI
PubMed ID