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ID 56203
フルテキストURL
著者
Takamura, Hiroyoshi Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Ohashi, Takumi Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Kikuchi, Takahiro Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Endo, Noriyuki Himeji EcoTech Co., Ltd.
Fukuda, Yuji Himeji EcoTech Co., Ltd.
Kadota, Isao Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
抄録
Hybrid molecules consisting of geraniol and butenolide were designed and synthesized by the late-stage divergent strategy. In the synthetic route, ring-closing metathesis was utilized for the construction of a butenolide moiety. A biological evaluation of the eight synthetic hybrid compounds revealed that these molecules exhibit antifouling activity against the cypris larvae of the barnacle Balanus (Amphibalanus) amphitrite with EC50 values of 0.30-1.31 μg mL-1. These results show that hybridization of the geraniol and butenolide structural motifs resulted in the enhancement of the antifouling activity.
備考
This is an Accepted Manuscript of an article published by Royal Society of Chemistry
We are grateful to Okayama Foundation for Science and Technology and The Yakumo Foundation for Environmental Science for financial support.
発行日
2017-06-13
出版物タイトル
Organic and Biomolecular Chemistry
15巻
26号
出版者
Royal Society of Chemistry
開始ページ
5549
終了ページ
5555
ISSN
14770520
NCID
AA1168650X
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
論文のバージョン
author
PubMed ID
DOI
Web of Sience KeyUT
関連URL
isVersionOf https://doi.org/10.1039/c7ob01160a