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ID 32300
JaLCDOI
フルテキストURL
Thumnail fulltext.pdf 1.43 MB
著者
Nakamura, Koki Okayama University
Irie, Hiroyuki Okayama University
Fujisawa, Emi Okayama University
Yoshioka, Hidekatsu Okayama University
Ninomiya, Yoshifumi Okayama University
Sakuma, Isao Okayama University
Sano, Shunji Okayama University
抄録

While heat shock protein (HSP) 72 is known as a stress protein, there have been no reports of HSP 72 expression in patients who have undergone surgery for congenital heart disease. Fourteen patients (7 males and 7 females) who had undergone surgery for congenital heart disease were studied. The ages of the patients ranged from 2 months to 43 years old (mean 6.5 +/- 10.8 years old; median 3.0 years old). The diagnoses were Tetralogy of Fallot in seven, pulmonary atresia with ventricular septal defect (VSD) in three, complex anomalies in three, and VSD in one patient. Histological study and HSP analysis using Western blots and immunostaining with anti-HSP 72 monoclonal antibody were performed for right ventricular muscle samples resected during the surgery. The histological findings showed hypertrophic changes of ventricular cardiomyocytes in all samples studied. Western blots detected HSP 72 expression of various degrees in all specimens. Immunostaining using monoclonal antibody against HSP 72 showed that the protein was present in the nuclei and cytoplasm of cardiomyocytes. In conclusion, although it is difficult to determine the cause of the "stress" that triggers HSP 72 expression in cardiomyocytes, low O2 saturation and pressure overload might act as a "stress", and the only common factor that induced HSP 72 in every sample was hypertrophy.

キーワード
heat shock protein 72 (HSP 72)
human
heart
congentional cardiac surgery
hypertrophy
Amo Type
Article
発行日
2000-06
出版物タイトル
Acta Medica Okayama
54巻
3号
出版者
Okayama University Medical School
開始ページ
103
終了ページ
109
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT