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ID 31028
JaLCDOI
フルテキストURL
著者
Wakiguchi, Hiroshi Kochi Medical School
Fujieda, Mikiya Kochi Medical School
Matsumoto, Kenji Kochi Medical School
Ohara, Yuji Kochi Medical School
Wakiguchi, Akiko Kochi Medical School
Kurashige, Takanobu Kochi Medical School
抄録

Natural killer (NK) cell activity, lymphokine activated killer (LAK) activity and Epstein-Barr virus specific cytotoxic T lymphocyte (EBV-CTL) activity were examined in 10 children with chronic active EB-virus infection and an adult with persistently positive early antigen-antibody to EB-virus. NK cell activity against erythroleukemia cell line K-562 was significantly (p less than 0.005) lower in the patients (22.3 +/- 8.5%, mean +/- SD) than in normal controls (40.4 +/- 15.9%). Spontaneous cytotoxicity against an EB-virus transformed autologous lymphoblastoid cell line was 15.0 +/- 7.6% in the patients, and was comparable to spontaneous cytotoxicity activity in normal controls (11.7 +/- 4.3%). LAK activity against Raji cells was significantly (p less than 0.02) lower in the patients (14.6 +/- 11.4%) than in normal controls (29.2 +/- 15.9%). EBV-CTL activity against an EB-virus transformed autologous lymphoblastoid cell line was significantly (p less than 0.005) lower in the patients (11.8 +/- 5.5%) than in seropositive normal controls (33.7 +/- 14.7%). No regression of the lymphoblastoid cell line was observed when EBV-CTL activity of the patients was tested by regression assay. It is conceivable that defects in both EB-virus specific and nonspecific killer cell activities play important roles in the pathogenetic abnormalities which allow EB-virus infection to progress to a chronic active state.

キーワード
chronic active EB-virus infection
EB-virus specific cytotoxic T lymphocyte
natural killer
lymphokine activated killer
Amo Type
Article
発行日
1988-06
出版物タイトル
Acta Medica Okayama
42巻
3号
出版者
Okayama University Medical School
開始ページ
137
終了ページ
142
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT