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ID 32825
JaLCDOI
フルテキストURL
著者
Nakajima, Hirofumi Okayama University
Shimomura, Hiroyuki Okayama University
Iwasaki, Yoshiaki Okayama University
Ikeda, Fusao Okayama University
Umeoka, Fumi Okayama University
Chengyu, Piao Okayama University
Taniguchi, Hideaki Okayama University
Ohnishi, Yasuhiro Okayama University
Takagi, Shin-jiro Okayama University
Fujioka, Shin-ichi Okayama University
Shiratori, Yasushi Okayama University
抄録

To improve the efficacy of interferon (IFN) treatment for chronic hepatitis C, we have proposed the twice-daily administration of IFN-beta as a promising induction therapy. In this study, we demonstrated differences between the clearance of circulating HCV-RNA and the induction of anti-viral actions during the first 2 weeks of treatment. Nine patients with a high viral load and genotype 1b were randomly assigned to 3 groups: group A received 3MU of IFN-beta twice a day at intervals of 5 and 19 h; group B received 3MU of IFN-beta twice a day at intervals of 10 and 14 h; group C received 6MU of IFN-alpha once a day with ribavirin. The expression of OAS2, PKR, and MxA in peripheral blood mononuclear cells (PBMCs) were quantified by real-time polymerase chain reaction method. The viral clearance showed a bi-phasic pattern, and those in the second phase of groups A and B were significantly steeper than that of group C. The peak level of OAS2 during the first phase was correlated with the first phase decay. The MxA expression tended to be higher in group A and B than in group C. The expression of these 3 proteins tended to decrease at day 6 in group C, but increase in groups A and B. These might make differences in the viral decay during the second phase

キーワード
chronic hepatitis C(CHC)
interferon(IFN)beta
hepatitis C virus(HCV)dynamics
antiviral actions
real time PCR
Amo Type
Article
発行日
2003-10
出版物タイトル
Acta Medica Okayama
57巻
5号
出版者
Okayama University Medical School
開始ページ
217
終了ページ
225
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT