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ID 49930
フルテキストURL
著者
Nakatsukasa, Yoko Perineito Hahatokono Hosp Mothers & Children, Dept Pediat
Tsukahara, Hirokazu Okayama Univ, Dept Pediat, Grad Sch Med Dent & Pharmaceut Sci
Tabuchi, Kazuhisa Perineito Hahatokono Hosp Mothers & Children, Dept Gynecol & Obstet
Tabuchi, Masako Perineito Hahatokono Hosp Mothers & Children, Dept Gynecol & Obstet
Magami, Tomoko Perineito Hahatokono Hosp Mothers & Children, Dept Gynecol & Obstet
Yamada, Mutsuko Okayama Univ, Dept Pediat, Grad Sch Med Dent & Pharmaceut Sci
Fujii, Yosuke Okayama Univ, Dept Pediat, Grad Sch Med Dent & Pharmaceut Sci
Yashiro, Masato Okayama Univ, Dept Pediat, Grad Sch Med Dent & Pharmaceut Sci
Tsuge, Mitsuru Okayama Univ, Dept Pediat, Grad Sch Med Dent & Pharmaceut Sci
Morishima, Tsuneo Okayama Univ, Dept Pediat, Grad Sch Med Dent & Pharmaceut Sci
抄録
This study examined the clinical and biological importance of thioredoxin-1, a redox-active defensive protein that controls multiple biological functions, in pregnant women. We measured serum concentrations of thioredoxin-1, total hydroperoxides, and redox potential in 60 pregnant women at the early third trimester: gestational age of 27-29 weeks. The thioredoxin-1 concentration (mean +/- SD) was 90 +/- 42 ng/ml. Total hydroperoxides was 471 +/- 105 U.CARR (1 U.CARR = 0.08 mg/dl H2O2). Redox potential was 2142 +/- 273 mu mol/l. The total hydroperoxides: redox potential ratio (oxidative stress index) was 0.23 +/- 0.08. Thioredoxin-1, total hydroperoxides, and oxidative stress index were higher and redox potential was lower than in blood of healthy adults. Total hydroperoxides and redox potential were mutually correlated significantly and negatively. Thioredoxin-1 correlated significantly and negatively and redox potential correlated significantly and positively with body weight and body mass index. Thioredoxin-1 and redox potential correlated significantly and positively with uric acid and albumin, respectively. Thioredoxin-1 and oxidative stress index correlated significantly and negatively and redox potential significantly and positively with neonatal birth weight. These results suggest that high concentrations of thioredoxin-1 are linked to high oxidative stress status in pregnant women and that neonatal birth weight is affected by the maternal oxidative condition during later pregnancy.
キーワード
later pregnancy
oxidative stress
redox potential
thioredoxin
total hydroperoxides
発行日
2013-01-01
出版物タイトル
Journal of Clinical Biochemistry and Nutrition
52巻
1号
出版者
The Editorial Secretariat of JCBN
開始ページ
27
終了ページ
31
ISSN
0912-0009
NCID
AA10710201
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.3164/jcbn.12-71
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/49721
言語
English
論文のバージョン
publisher
査読
有り
DOI
Web of Sience KeyUT