JaLCDOI 10.18926/AMO/32214
フルテキストURL fulltext.pdf
著者 Arao, Yujiro| Hatano, Atsushi| Yamada, Masao| Uno, Fumio| Nii, Shiro|
抄録 <p>In order to elucidate the mechanism of latent infection of herpes simplex virus (HSV), reactivatable latency of three avirulent strains (SKO-1B, -GCr Miyama, SKa) of HSV type 1 was comparatively examined in a mouse latency model. The SKO-1B strain showed high rate of virus reactivation from explanted trigeminal ganglia without n-butyrate enhancement, while the other two strains showed a very low rate of virus reactivation in the absence of n-butyrate. In the presence of n-butyrate, however, the rate of the -GCr Miyama strain jumped to a comparable level with that of SKO-1B, although the rate of SKa remained at a low level. A more precise follow-up experiment changing the virus dose highlighted the difference of the ability to reactivate from the latent state between SKO-1B and -GCr Miyama. Virus titer in trigeminal ganglia during acute phase, infectivity to cell lines of neural origin, and susceptibility to acyclovir and phosphonoacetate were assayed to know the reasons for the variation in the ability of reactivatable latency among these strains. It was concluded that the reduced infectivity to neural cells, and limited ability of reactivatable latency shown by the SKa strain could mainly be attributed to the deficiency of thymidine kinase activity.&#60;/P&#62;</p>
キーワード herpes simplex virus type 1 neurovirulence latency reactivation n-butyrate
Amo Type Article
発行日 1991-02
出版物タイトル Acta Medica Okayama
45巻
1号
出版者 Okayama University Medical School
開始ページ 43
終了ページ 47
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1648298
Web of Sience KeyUT A1991FA75000006
JaLCDOI 10.18926/AMO/32190
フルテキストURL fulltext.pdf
著者 Arao, Yujiro| Hatano, Atsushi| Yamada, Masao| Uno, Fumio| Nii, Shiro|
抄録 <p>Ability of two neurovirulent strains (F and +GC (LPV) Miyama) of herpes simplex virus type 1 (HSV-1) to establish and maintain reactivatable latency in trigeminal ganglia (TG) was compared after intranasal inoculation of mice. The +GC (LPV) Miyama strain showed a very low rate of virus reactivation in explant cultures of TG, while the F strain showed a high rate of reactivation. These data indicate that neurovirulent strains of HSV-1 are not always competent for reactivatable latency, although most virulent strains of HSV-1 thus far reported were competent for reactivatable latency.&#60;/P&#62;</p>
キーワード herpes simplex virus type 1 neurovirulence latency reactivation
Amo Type Article
発行日 1991-04
出版物タイトル Acta Medica Okayama
45巻
2号
出版者 Okayama University Medical School
開始ページ 117
終了ページ 121
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1651044
Web of Sience KeyUT A1991FL60800008