JaLCDOI 10.18926/AMO/31651
フルテキストURL fulltext.pdf
著者 Seven, Arzu| Tasan, Ertugrul| Hatemi, Husrev| Burcak, Gulden|
抄録 <p>This study was performed on 17 hyperthyroid patients and 15 healthy controls. The patients were under propylthiouracil (PTU) therapy at a dosage of 3 x 100 mg/day for one month. Blood samples, taken at the beginning and on the 30th day of therapy, were analyzed for hormonal parameters (T3, T4, TSH), lipid peroxidation endproduct [thiobarbituric acid reactive substances (TBARS)] and antioxidant status parameters: glutathione (GSH), glutathione peroxidase (GSH-Px) and CuZn superoxide dismutase (CuZn SOD). Hyperthyroid patients were observed to have significantly higher TBARS, GSH and CuZn SOD levels than controls (P &#60; 0.05, P &#60; 0.001, P &#60; 0.001, respectively). PTU therapy caused a relief in oxidative stress as reflected by significantly decreased TBARS levels (P &#60; 0.001) and a selective modification in the antioxidant status parameters: significant decreases in GSH and CuZn SOD levels (P &#60; 0.001) and a significant increase in GSH Px (P &#60; 0.01) activity. Our findings suggest a selective modification of the antioxidative profile in hyperthyroidism. PTU should also be considered as an in vivo antioxidant, in addition to its antithyroid action.</p>
キーワード propylthiouracil hyperthyroidism glutathione glutathione peroxidase superoxide dismutase lipid peroxidation
Amo Type Article
発行日 1999-02
出版物タイトル Acta Medica Okayama
53巻
1号
出版者 Okayama University Medical School
開始ページ 27
終了ページ 30
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
Web of Sience KeyUT 000078897700005
JaLCDOI 10.18926/AMO/31620
フルテキストURL fulltext.pdf
著者 Dincer, Yildiz| Akcay, Tulay| Konukoglu, Dildar| Hatemi, Husrev|
抄録 <p>In recent years it has been reported that free oxygen radicals play an important role in the pathogenesis of degenerative diseases and that antioxidant vitamins such as vitamins E or C prevent their harmful effects. In this study, we evaluated the following: Erythrocyte susceptibility to lipid peroxidation; the role of erythrocyte glutathione (GSH) as an antioxidant; plasma lipid fractions; and the relationship between plasma lipid peroxides and antioxidant vitamin levels. Thiobarbituric acid-reactive substance (TBARS) levels were measured to determine the levels of plasma lipid peroxides and the susceptibility to lipid peroxidation when erythrocytes were stressed by hydrogen peroxide for 2 h in vitro. Erythrocyte TBARS production was significantly higher in patients with coronary atherosclerosis than in the controls. On the other hand, the levels of plasma high-density lipoproteins, vitamin C, vitamin E and erythrocyte GSH were significantly lower, and the levels of plasma total cholesterol, triglycerides, low-density lipoproteins and TBARS were significantly higher in the patients with coronary atherosclerosis than in the controls. In conclusion, our results indicate that erythrocytes from patients with coronary atherosclerosis are more susceptible to oxidation than those of controls and that these patients have lowered antioxidant capacity as revealed by decreased plasma levels of vitamins C and E.</p>
キーワード atherosclerosis vitamin C vitamin E malondialdehyde glutathione
Amo Type Article
発行日 1999-12
出版物タイトル Acta Medica Okayama
53巻
6号
出版者 Okayama University Medical School
開始ページ 259
終了ページ 264
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 10631380
Web of Sience KeyUT 000084414300003
JaLCDOI 10.18926/AMO/30797
フルテキストURL fulltext.pdf
著者 Seymen, Oktay| Seven, Arzu| Candan, Gulden| Yigit, Gunnur| Hatemi, Sezer| Hatemi, Husrev|
抄録 <p>Our aim was to study the effect of iron supplementation on the following aspects of erythrocyte metabolism in experimental hyperthyroidism: glutathione (GSH) levels, glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities. Hyperthyroidism induced by L-thyroxine administrations significantly raised erythrocyte GSH, GSH-Px and SOD levels of the rats (P &#60; 0.001). Likewise, we observed that iron supplementation induced significant rises in erythrocyte GSH, GSH-Px and SOD levels (P &#60; 0.001) as compared with the control group. The erythrocyte GSH, GSH-Px and SOD levels of hyperthyroidism-induced iron-supplemented animals were significantly higher when compared with either the iron-supplemented group (P &#60; 0.001) or the only L-thyroxine-administered hyperthyroid group (P &#60; 0.001, P &#60; 0.05, P &#60; 0.01, respectively). The results of this study show that L-thyroxine administration and/or iron supplementation increases GSH, GSH-Px and SOD levels of erythrocytes.</p>
キーワード iron hyperthyroidism glutathione superoxide dismutase glutathione peroxidase
Amo Type Article
発行日 1997-06
出版物タイトル Acta Medica Okayama
51巻
3号
出版者 Okayama University Medical School
開始ページ 129
終了ページ 133
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9227791
Web of Sience KeyUT A1997XJ12700003