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ID 30797
JaLCDOI
フルテキストURL
著者
Seymen, Oktay Istanbul University
Seven, Arzu Istanbul University
Candan, Gulden Istanbul University
Yigit, Gunnur Okayama University
Hatemi, Sezer Okayama University
Hatemi, Husrev Istanbul University
抄録

Our aim was to study the effect of iron supplementation on the following aspects of erythrocyte metabolism in experimental hyperthyroidism: glutathione (GSH) levels, glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities. Hyperthyroidism induced by L-thyroxine administrations significantly raised erythrocyte GSH, GSH-Px and SOD levels of the rats (P < 0.001). Likewise, we observed that iron supplementation induced significant rises in erythrocyte GSH, GSH-Px and SOD levels (P < 0.001) as compared with the control group. The erythrocyte GSH, GSH-Px and SOD levels of hyperthyroidism-induced iron-supplemented animals were significantly higher when compared with either the iron-supplemented group (P < 0.001) or the only L-thyroxine-administered hyperthyroid group (P < 0.001, P < 0.05, P < 0.01, respectively). The results of this study show that L-thyroxine administration and/or iron supplementation increases GSH, GSH-Px and SOD levels of erythrocytes.

キーワード
iron
hyperthyroidism
glutathione
superoxide dismutase
glutathione peroxidase
Amo Type
Article
発行日
1997-06
出版物タイトル
Acta Medica Okayama
51巻
3号
出版者
Okayama University Medical School
開始ページ
129
終了ページ
133
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT