JaLCDOI 10.18926/AMO/30705
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Hara, Masamichi| Uchida, Kozaburo| Takaoka, Kazuko| Watanabe, Seiichiro| Lai, Minyu| Hamasaki, Kazuhide| Kohi, Fumikazu| Kitajima, Koichi| Kimura, Ikuro| Adachi, Tomiro| Yorimitsu, Seiichi| Tokioka, Masaaki| Sanada, Hiroshi|
抄録 <p>Relapses in nine patients with acute myelocytic leukemia were treated with a combination of aclarubicin (ACR) and cytosine arabinoside (ara-C). ACR, 40 mg/m2/day, was administered daily by intravenous injection from day 1 to day 3 and ara-C, 60-80 mg/m2/day, divided into 2 doses, was given every 12 h by intravenous infusion from day 1 to day 7. Depending on the state of the bone marrow, ACR-ara-C regimen was modified in administration period and repeated after the resting periods of at least 7 days. Complete remission was obtained in 7 of 9 patients (77.8%). The time required for achieving the complete remission varied from 20 to 55 days with a median of 39 days. The duration of complete remission was from 8 to 52 weeks with a median of 22 weeks. Side effects on digestive system such as nausea, vomiting and anorexia, were seen in all patients, although they were managed by symptomatic treatment. The results indicate the effectiveness of this ACR-ara-C regimen in the clinical management of acute nonlymphocytic leukemia.</p>
キーワード aclarubicin cytosine arabinoside chemotherapy acute myelocytic leukemia
Amo Type Brief Note
発行日 1982-02
出版物タイトル Acta Medica Okayama
36巻
1号
出版者 Okayama University Medical School
開始ページ 77
終了ページ 80
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6950658
Web of Sience KeyUT A1982NE20000009
JaLCDOI 10.18926/AMO/30706
フルテキストURL fulltext.pdf
著者 Hamasaki, Kazuhide|
抄録 <p>Six established Japanese Burkitt lymphoma (BL) cell lines including one case with null cell type were studied by chromosomal banding techniques. The modal chromosome number was diploid or nearly diploid in five cases and hyperdiploid in one case. The marker chromosome 14q+ was observed in four of the six cases; the origin of the extra band was a chromosome 8 in three including the null cell case but could not be identified in the other. The two cases lacking the 14q+ marker had variant translocations involving the long arm of chromosome 8, one of which carried a translocation, t(8;22) (q24;q13) and the other a translocation, t(2;8) (p12;q24). Although structural and/or numerical aberrations were found in all six cell lines, chromosome 8 was the one most consistently involved. This frequent involvement of chromosome 8 in aberrations; therefore, may be an important event in the development of BL rather than the presence of a 14q+ marker chromosome.</p>
キーワード non-African Burkitt lymphoma cell line null cell type Burlitt lymphoma cell line translocation
Amo Type Article
発行日 1982-02
出版物タイトル Acta Medica Okayama
36巻
1号
出版者 Okayama University Medical School
開始ページ 23
終了ページ 38
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7064731
Web of Sience KeyUT A1982NE20000003
JaLCDOI 10.18926/AMO/30566
フルテキストURL fulltext.pdf
著者 Miyamoto, Kanji| Miyano, Keiko| Miyoshi, Isao| Hamasaki, Kazuhide| Nishihara, Ryuji| Terao, Seiya| Kimura, Ikuro| Maeda, Kenichiro| Matsumura, Kazuyoshi| Mishijima, Katsumi| Tanaka, Toshio|
抄録 <p>Cytogenetic studies were performed on a biopsy specimen of a jaw tumor and on a bone marrow aspirate from a Japanese patient with Epstein-Barr virus-negative Burkitt's lymphoma. A 14q + chromosome was found in cells from either source, although each contained a different clone. Other karyotypic abnormalities present in common included 2dir dup (1q) (q21 leads to q32), 3q+, 6p--, +12, +mar.</p>
キーワード non-African Burkitt's lymphoma chromosome 14q+.
Amo Type Brief Note
発行日 1980-02
出版物タイトル Acta Medica Okayama
34巻
1号
出版者 Okayama University Medical School
開始ページ 61
終了ページ 65
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6446841
Web of Sience KeyUT A1980JS13800008
JaLCDOI 10.18926/AMO/31265
フルテキストURL fulltext.pdf
著者 Miyamoto, Kanji| Hamasaki, Kazuhide| Kitajima, Koichi| Adachi, Tomiro| Tanaka, Toshio| Sato, Jiro|
抄録 <p>Partial excess of chromosome 1 (q25-q32) was noted in malignant cells from all of 10 patients who had disorders such as non-African Burkitt's lymphoma, adult T-cell leukemia, myelofibrosis, malignant lymphoma, chronic lymphocytic leukemia or chronic myelocytic leukemia in blast crisis. The break points on chromosome 1 were at centromere, q12, q21, q23, q25 and q32. Variations in the specific region of the long arm of chromosome 1, q25-q32, were thought to be important in the evolution of malignant cell proliferation.</p>
キーワード chromosome no. 1 malignant lympoma leukemia chromosome aberration.
Amo Type Article
発行日 1981-04
出版物タイトル Acta Medica Okayama
35巻
2号
出版者 Okayama University Medical School
開始ページ 137
終了ページ 141
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6456645
Web of Sience KeyUT A1981LS45700006
JaLCDOI 10.18926/AMO/30519
フルテキストURL fulltext.pdf
著者 Lai, Miinyuh| Hamasaki, Kazuhide| Tokioka, Masaaki| Tsubota, Teruhiko| Nakata, Yasunari| Kitajima, Koichi| Kimura, Ikuro| Sanada, Hiroshi|
抄録 <p>A 30 year old female patient diagnosed as acute lymphoblastic leukemia (ALL) with hand mirror like configuration of lymphoblastic-lymphocytic cells is reported. Although the leukemia was resistant to conventional chemotherapeutic regimens, the patient always looked well and survived for more than 20 months. Surface marker analysis showed that the cell was non-T, non-B, and not reactive to antiserum against common ALL antigen. A cytogenetic study of all the analyzable metaphases of the direct bone marrow preparation had a normal female karyotype. The clinical and hematological course is described. The immunological significance and the influence of hand mirror cell on chemosensitivity and prognosis are discussed.</p>
キーワード acute lymphoblastic leukemia hand mirror cell leukemia.
Amo Type Brief Note
発行日 1980-09
出版物タイトル Acta Medica Okayama
34巻
4号
出版者 Okayama University Medical School
開始ページ 283
終了ページ 287
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6452031
Web of Sience KeyUT A1980KK16800007