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ID 31509
JaLCDOI
フルテキストURL
Thumnail fulltext.pdf 1.62 MB
著者
Hamaya, Kazuo Okayama Saiseikai General Hospital
Doi, Kenji Okayama Saiseikai General Hospital
Tanaka, Toshio Okayama University
Nishimoto, Akira Okayama University
抄録

Glial fibrillary acidic protein (GFAP) was purified from human spinal cord and cerebral white matter. GFAP was localized by an immuno-peroxidase method in normal adult and fetal human brains, rat brains, and 152 central nervous system (CNS) tumors. GFAP was found in reactive and normal astrocytes, immature cells of fetal brain at the 18th to 21st gestational weeks, and normal rat astrocytes. This GFAP staining was quite specific for glial tumors, including astrocytomas, glioblastomas, astroblastomas, and ependymomas. GFAP-positive cells were also found in oligodendrogliomas and choroid plexus papillomas, and they were interpreted as being astroglial or ependymal differentiations. Stromal cells in cerebellar hemangioblastomas were negative. However, engulfed astrocytes were found at the periphery of such tumors and often adjacent to the proliferate blood vessels. In meningiomas, neurinomas, metastatic carcinomas, pituitary adenomas and other non-glial tumors, GFAP-positive cells were not identified.

キーワード
glial librillary acidic protein
central nervous system tumors
Amo Type
Article
発行日
1985-12
出版物タイトル
Acta Medica Okayama
39巻
6号
出版者
Okayama University Medical School
開始ページ
453
終了ページ
462
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT