JaLCDOI 10.18926/AMO/31764
フルテキストURL fulltext.pdf
著者 Nishiya, Koji| Yamamura, Masahiro| Hatano, Makoto| Amano, Tetsuki| Suzuki, Shinya| Ota, Zensuke|
抄録 <p>Human peripheral blood mononuclear cells (PBM) were separated into sheep erythrocyte rosette-forming (Es+) and non Es+ cells by the Ficoll-Hypaque gradient sedimentation method. Thirty-eight percent of the Es+ cells formed rosettes with dog erythrocytes and were designated as Es+Ed+ cells. The remaining Es+ cells were designated as Es+Ed- cells. Only a few non Es+ cells formed rosettes with dog erythrocytes. Among Es+Ed+ cells, T4 antigen-positive cells were observed approximately 1.7 times as often as T8 antigen-positive cells, when measured by staining with OKT4 or OKT8 monoclonal antibody. Among Es+Ed- cells, however, T4 and T8 antigen-positive cells were observed in almost equal proportion. Preincubation of PBM with OKT11 monoclonal antibody, but not with OKT4 monoclonal antibody, inhibited the rosette formation with dog as well as sheep erythrocytes. These results indicated that Es+Ed+ cells were a subpopulation of T-cells in which a majority of the cells were T4 antigen-positive, and that the binding sites of dog erythrocytes on human T-cells was closely linked with that of sheep erythrocytes.</p>
キーワード dog erythrocyte rosette formation T-cells E-receptor OKT11
Amo Type Article
発行日 1987-02
出版物タイトル Acta Medica Okayama
41巻
1号
出版者 Okayama University Medical School
開始ページ 37
終了ページ 41
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3105252
Web of Sience KeyUT A1987G146400006
JaLCDOI 10.18926/AMO/31499
フルテキストURL fulltext.pdf
著者 Nishiya, Koji| Matsueda, Hideki| Shirakami, Toshiaki| Hatano, Makoto| Yano, Keisuke| Ogura, Toshiro| Takaoka, Michio| Hiraki, Yoshio| Aono, Kaname| Ezawa, Hidemitsu| Ota, Zensuke|
抄録 <p>The serum and urinary ferritin levels in 52 RA patients were measured by the 2-site immunoradiometric assay method. Serum ferritin levels in RA patients correlated with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) but not with serum iron levels and hemoglobin concentrations, although they were within the normal range. High serum ferritin levels were associated with sera with hyper gamma-globulin and rheumatoid factors. In sequential studies, serum ferritin changed in parallel with ESR, CRP and disease activity in a majority of the patients. The urinary ferritin levels and u/s ratios in some RA patients were higher than control values. Higher values were found particularly in the group of patients under gold therapy but not in groups under other treatments.</p>
キーワード rheumatoid arthritis serum ferritin urinary ferritin gold therapy
Amo Type Article
発行日 1985-08
出版物タイトル Acta Medica Okayama
39巻
4号
出版者 Okayama University Medical School
開始ページ 321
終了ページ 328
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2413723
Web of Sience KeyUT A1985APN0700008