JaLCDOI 10.18926/AMO/31008
フルテキストURL fulltext.pdf
著者 Saito, Daiji| Ueeda, Masayuki| Hina, Kazuyoshi| Watanabe, Hirofumi| Mima, Tsutomu| Hasui, Masahiro| Yamada, Nobuyuki| Haraoka, Shoichi| Tsuji, Takao|
抄録 <p>The effect of the heart rate and myocardial contractile force on the extravascular resistance to blood flow of the left anterior descending coronary artery (LAD) was evaluated in 15 mongrel dogs anesthetized with sodium pentobarbital. The LAD was maximally dilated by intracoronary infusion of adenosine, which precluded the influence of vasomotor tone. Increases in the heart rate and myocardial contractile force decreased coronary blood flow in the absence of a change in coronary perfusion pressure. The changes in mean coronary resistance showed a significant linear relationship to changes in developed tension. The changes in coronary resistance caused by varying the heart rate and contractile force were so small that a normal coronary vascular tree could easily compensate for the increase in resistance. However, it is supposed that with critical stenosis of the vascular tree even a small increase in resistance might cause deleterious effects on coronary blood flow.</p>
キーワード contractile force tachycardia extravascular resistance coronary flow adenosine
Amo Type Article
発行日 1988-12
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 335
終了ページ 342
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3239438
Web of Sience KeyUT A1988R743300005