JaLCDOI 10.18926/AMO/32449
フルテキストURL fulltext.pdf
著者 Kawaguchi, Kenji| Itoshima, Tatsuya| Ukida, Minoru| Ito, Toshio| Kiyotoshi, Shozo| Ogawa, Hiromichi| Hattori, Shuzo| Kitadai, Masahiro| Mizutani, Shigeki| Nagashima, Hideo|
抄録 <p>The incidence of intraperitoneal adhesion after abdominal surgery was studied. Peritoneoscopy was performed in 933 patients with liver diseases over the 6 year 5 month period from March 1974 to July 1980. Of the patients, 352 (37.7%) had undergone an abdominal operation, and intraperitoneal adhesion was detected in 205 (58.2%) of these patients. The liver was not observable in 5 out of 61 patients with adhesions after upper abdominal operations. Whereas, the liver was clearly observable in patients with lower abdominal operations in spite of adhesions. Out of the 581 patients without any abdominal operations, 30 patients (5.2%) had adhesions in the abdominal cavity, and 6 of them had extensive adhesions that partially obscured the observation of liver surface. In all patients, peritoneoscopy was performed without complications by avoiding the surgical scar for puncture sites and ensuring a free air lumen before trocar puncture.</p>
キーワード peritoneoscopy liver adhesion abdominal operation
Amo Type Article
発行日 1983-02
出版物タイトル Acta Medica Okayama
37巻
1号
出版者 Okayama University Medical School
開始ページ 67
終了ページ 72
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6221509
Web of Sience KeyUT A1983QD83600008
JaLCDOI 10.18926/AMO/32398
フルテキストURL fulltext.pdf
著者 Ito, Toshio| Yamamoto, Hiroshi| Itoshima, Tatsuya| Ukida, Minoru| Ogawa, Hiromichi| Kitadai, Masahiro| Hattori, Shuzo| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Yamauchi, Yasuhiko| Hashimoto, Keiji| Hayashi, Hidehiro| Aono, Kaname| Nagashima, Hideo|
抄録 <p>Computed tomographic arteriography (CTA) was performed in 30 patients with hepatocellular carcinoma (HCC). Detection of HCC by CTA was compared with that of conventional celiac or hepatic arteriography. CT scanning was performed immediately, 30 seconds and 1 min after an injection of 5 to 10 ml of contrast medium into the common or proper hepatic artery. Repeated infusions allowed whole liver sections to be visualized. HCC was localized in 28 of the 30 patients by conventional arteriography, with CTA detecting the masses in 27 of the 28 patients. CTA imaging presented the tumor mass in 1 of the 2 patients missed by arteriography. Conventional arteriography delineated the boundaries of HCC in 15 (50%) of the 30 patients. CTA clearly delineated the masses in 26 (87%) of the 30 patients including 11 patients in which the tumor borders were obscure by conventional arteriography. HCC lesions smaller than 1 cm in diameter were detected only by CTA in 6 (20%) of the patients. It was concluded that CTA is both useful and necessary in the demarcation of small HCC masses.</p>
キーワード computed tomographic arteriography hepatocellular carcinoma hepatic arteriography contrast enhancement
Amo Type Article
発行日 1983-12
出版物タイトル Acta Medica Okayama
37巻
6号
出版者 Okayama University Medical School
開始ページ 503
終了ページ 510
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6320600
Web of Sience KeyUT A1983RW62800006
JaLCDOI 10.18926/AMO/31539
フルテキストURL fulltext.pdf
著者 Kitadai, Masahiro| Itoshima, Tatsuya| Hattori, Shuzo| Ukida, Minoru| Ito, Toshio| Ogawa, Hiromichi| Mizutani, Shigeki| Tanaka, Ryoji| Kita, Keiji| Nagashima, Hideo|
抄録 <p>Sixty-seven cases of alcoholic liver disease were histologically classified into 4 groups: alcoholic liver cirrhosis (ALC), alcoholic hepatitis (AH), alcoholic liver fibrosis (ALF) and alcoholic fatty liver (AFL). They were statistically reclassified by the likelihood method using age, total alcohol intake, hepatomegaly and 12 liver function tests. A score table for likely diagnosis was constructed from the incidences of each range. The cases were re-evaluated using the score table, with an overall correct diagnosis rate of 73%. The best combination of 5 parameters included the indocyanine green plasma disappearance rate, total alcohol intake, cholesterol, choline esterase and glutamic oxaloacetic transaminase/glutamic pyruvic transaminase ratio. A correct diagnosis rate of 75% was attained using these 5 parameters, and 94% of patients were correctly diagnosed by the first or the second likelihood diagnosis. Differential diagnosis of alcoholic liver diseases was easily and confidently obtained with the likelihood score table.</p>
キーワード alcoholic liver diseases multivariate analaysis liver function tests
Amo Type Article
発行日 1985-02
出版物タイトル Acta Medica Okayama
39巻
1号
出版者 Okayama University Medical School
開始ページ 11
終了ページ 18
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3984778
Web of Sience KeyUT A1985ACS5600002
JaLCDOI 10.18926/AMO/31518
フルテキストURL fulltext.pdf
著者 Tanaka, Ryoji| Itoshima, Tatsuya| Ukida, Minoru| Ito, Toshio| Kitadai, Masahiro| Hattori, Shuzo| Mizutani, Shigeki| Kita, Keiji| Nagashima, Hideo|
抄録 <p>Three linear plots by which the liver's maximum removal rate (Rmax) of indocyanine green (ICG) and the Michaelis constant (Km) can be calculated were compared in a microcomputer simulation study. The widely-used Lineweaver-Burk plot (1/V vs. 1/S; V, ICG initial removal rate (mg/kg/min); S, ICG loading dose (mg/kg] presented the greatest bias and variance. There was no remarkable difference in bias between the S/V vs. S plot and the V vs. V/S plot, but the latter possessed a smaller variance. Therefore, the V vs. V/S plot was considered the best for estimating Rmax. The best combination of three ICG loading doses was 0.5, 2, and 5 mg/kg. This combination was selected by comparison of the Rmax estimated from three points with that estimated from six points (0.5, 1, 2, 3, 4 and 5 mg/kg).</p>
キーワード indocyanine green liver's maximum removal rate liver function test simulation study
Amo Type Article
発行日 1985-04
出版物タイトル Acta Medica Okayama
39巻
2号
出版者 Okayama University Medical School
開始ページ 119
終了ページ 124
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 4003111
Web of Sience KeyUT A1985AGK4600006
JaLCDOI 10.18926/AMO/31514
フルテキストURL fulltext.pdf
著者 Kitadai, Masahiro| Hattori, Shuzo| Itoshima, Tatsuya| Ukida, Minoru| Ito, Toshio| Ogawa, Hiromichi| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Nagashima, Hideo|
抄録 <p>Peritoneoscopic findings of 39 patients with alcoholic liver cirrhosis (ALC) were compared with those of 95 patients with non-alcoholic liver cirrhosis (NALC). They were selected from 245 patients with liver cirrhosis subjected to peritoneoscopy in the 7 year period from 1975 to 1981. Out of the 95 NALC patients, 24 had hepatitis B surface antigen. The ALC patients had nodules which varied in size (61%), large depressions (69%), and a markedly rounded edge of the liver (33%) more often than NALC patients (18, 43 and 3%, respectively). Nodularity differed between the right and left lobes in ALC (41%) more often than in NALC (16%). Interstitial reddish markings and patchy nodules were, however, more frequent in NALC (51 and 28%, respectively) than in ALC (8 and 5%, respectively). Lymphatic vesicles were observed both in ALC (85%) and NALC (78%). In conclusion, the peritoneoscopic features which suggested ALC were the coexistence of nodules of various sizes, large depressions and a markedly dull edge of the liver. Interstitial reddish markings and patchy nodules were more indicative of NALC than ALC.</p>
キーワード peritoneoscopy alcoholic liver cirrhosis non-alcoholic liver cirrhosis
Amo Type Article
発行日 1985-04
出版物タイトル Acta Medica Okayama
39巻
2号
出版者 Okayama University Medical School
開始ページ 105
終了ページ 112
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3159179
Web of Sience KeyUT A1985AGK4600004
JaLCDOI 10.18926/AMO/30683
フルテキストURL fulltext.pdf
著者 Ito, Toshio| Itoshima, Tatsuya| Kiyotoshi, Shuzo| Kawaguchi, Kenji| Ogawa, Hiromichi| Kitadai, Masahiro| Hattori, Shuzo| Maruyama, Toshihiro| Tomoda, Jun| Morichika, Shigeru| Munetomo, Fumio| Nagashima, Hideo|
抄録 <p>Percutaneous transhepatic portal catheterization was performed in 68 cases of liver diseases in the 2 year period from 1978 to 1980. The Chiba University method was modified. Portal vein catheterization was successful in 61 cases (90%). Selective splenic vein catheterization was successful in 55 of the 61 cases (90%) and selective superior mesenteric vein catheterization in 59 cases (97%). The liver was punctured an average of 4.6 times in order to successfully insert the catheter into the main portal vein, and the number of punctures was less than 10 in 57 of the 61 cases (93%). The portal vein pressure was 310+/-67 mm H2O in idiopathic portal hypertension (8 cases), 290+/-83 in liver cirrhosis (33 cases), 193+/-71 in chronic hepatitis (7 cases) and 166+/-50 in fatty liver (4 cases). Portal vein pressure rose from 205+/-75 to 380+/-55 mm H2O in 11 cases after forced Valsalva maneuver. No major complications were encountered.</p>
キーワード percutaneous transhepatic portal catheterization(PTP) portal vein pressure portal hypertension forced Valsalva maneuver
Amo Type Article
発行日 1982-04
出版物タイトル Acta Medica Okayama
36巻
2号
出版者 Okayama University Medical School
開始ページ 147
終了ページ 156
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7136852
Web of Sience KeyUT A1982NM45300008
JaLCDOI 10.18926/AMO/30653
フルテキストURL fulltext.pdf
著者 Ito, Toshio| Itoshima, Tatsuya| Ukida, Minoru| Kiyotoshi, Shozo| Kawaguchi, Kenji| Ogawa, Hiromichi| Hattori, Shuzo| Kitadai, Masahiro|
抄録 <p>The portal vein system was clearly visualized in superior mesenteric arterial portography using prostaglandin E1. Angiographic examination was performed in 68 patients with various liver diseases during the 2 year period from 1980 to 1981. Twenty microgram of prostaglandin E1 was injected into the superior mesenteric artery 30 seconds before injection of 60 ml of contrast medium. The main portal vein was visualized in all of 68 cases. A high rate of success for visualization of the intrahepatic portal vein system by prostaglandin E1 was achieved. The first branches of the intrahepatic portal vein were visualized in 100% of the cases, the second branches in 82%, the third branches in 44%, and the fourth branches in 4% in the right portal vein system. In the left portal vein system, the first branches were visualized in 87%, the second branches in 41%, and the third branches in 3% of the cases. The intrahepatic portal vein system was more clearly visualized in females than in males (P less than 0.05). This procedure is simple, safe and useful for clear visualization of the portal vein system.</p>
キーワード superior mesenteric arteriography arterial portography portal vein system prostaglandin E1
Amo Type Article
発行日 1982-08
出版物タイトル Acta Medica Okayama
36巻
4号
出版者 Okayama University Medical School
開始ページ 291
終了ページ 297
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6890302
Web of Sience KeyUT A1982PE61100006
JaLCDOI 10.18926/AMO/30369
フルテキストURL fulltext.pdf
著者 Ito, Toshio| Itoshima, Tatsuya| Ukida, Minoru| Tobe, Kazuo| Kiyotoshi, Shozo| Kawaguchi, Keiji| Ogawa, Hiromichi| Yamamoto, Harumi| Hattori, Shuzo| Kitadai, Masahiro| Mizutani, Shigeki| Tsuchiya, Takahiro| Kita, Keiji| Tanaka, Ryoji| Nagasima, Hideo|
抄録 <p>The whole body including extended processes of Ito's fat-storing cells was observed by scanning electron microscopy in rat liver injured with lithocholic acid (LCA). Necrotic foci developed in the midlobular zone 48 h after LCA administration. Demonstration of Ito cell bodies around the foci was probably facilitated by easy detachment of hepatocytes from Ito cells. The body and the processes were located mainly between the sinusoidal endothelium and hepatocytes; sometimes they were between hepatocytes. Ito cells often were proximate to collagen fiber bundles and sometimes were attached to them. The cell body was flatly round or elliptic, 7 to 12 micron in diameter. Its surface was finely undulated with microvillous projections about 0.1 micron in length. Branching patterns of the processes resembled a fern-leaf mantling the sinusoidal endothelium. The trunks of the processes were about 2 micron in diameter and 20-30 micron in length. These processes tapered, branching into thinner processes, with the most peripheral being 0.1 micron in diameter. Ito cells and their branching processes likely strengthen sinusoidal walls and control blood flow in the sinusoids.</p>
キーワード ito cell fat-storing cell lithocholic acied liver cell necrosis scanning electron microscopy
Amo Type Article
発行日 1984-02
出版物タイトル Acta Medica Okayama
38巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 9
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6702480
Web of Sience KeyUT A1984SF03000001
JaLCDOI 10.18926/AMO/30328
フルテキストURL fulltext.pdf
著者 Itoshima, Tatsuya| Kawaguchi, Kenji| Ukida, Minoru| Ito, Toshio| Hattori, Shuzo| Kitadai, Masahiro| Ogawa, Hiromichi| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Nagashima, Hideo|
抄録 <p>Sex, age and 21 routine liver function assays were analyzed by stepwise selection and the best-of-all-possible-combinations method to identify a small group of assays valuable in establishing which liver cirrhosis (LC) patients have a high risk of hepatocellular carcinoma (HCC), when alpha-fetoprotein (AFP) is not elevated. Data was obtained from 115 HCC and 122 LC patients on admission. Tumor size correlated with AFP (0.73), alkaline phosphatase (ALP, 0.47), leucine aminopeptidase (LAP, 0.42), lactic dehydrogenase (LDH, 0.42), and the glutamic oxaloacetic transaminase (GOT)/glutamic pyruvic transaminase (GPT) ratio (GOT/GPT, 0.41). The mean of the correct diagnosis rates (CDR) of HCC and LC utilizing AFP as the sole parameter (89%) was markedly higher than those of the other parameters. The best-of-all-possible-combinations method presented a more powerful combination than stepwise selection. The best combination of 7 parameters (LAP, GOT/GPT, choline esterase, one-hour erythrocyte sedimentation rate, age, albumin/globulin ratio, and total bilirubin) presented a mean CDR of 80%, HCC CDR of 77%, and false positive rate of 18%. LC patients statistically diagnosed as having HCC by these 7 parameters are proposed as high risk patients. Fourteen (78%) of 18 HCC patients who were AFP-negative were statistically diagnosed. This analysis can be applied to LC patients to distinguish those that should be followed closely by imaging diagnostic techniques.</p>
キーワード hepatocellular carcinoma liver cirrhosis high risk hepatocellular carcinoma liver function tests differentical diagnosis
Amo Type Article
発行日 1984-04
出版物タイトル Acta Medica Okayama
38巻
2号
出版者 Okayama University Medical School
開始ページ 159
終了ページ 168
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6203337
Web of Sience KeyUT A1984SN81800007
JaLCDOI 10.18926/AMO/30323
フルテキストURL fulltext.pdf
著者 Kitadai, Masahiro| Hattori, Shuzo| Itoshima, Tatsuya| Ukida, Minoru| Ito, Toshio| Ogawa, Hiromichi| Mizutani, Shigeki| Kita, Keiji| Tanaka, Ryoji| Nagashima, Hideo|
抄録 <p>Sake or bourbon (8g ethanol/kg body weight) was intragastrically administered to rats for 12 days. An equal dose of ethanol in water or an isocaloric glucose solution was administered to control groups. Food was withheld, but water freely provided. Neither mortality nor liver and body weights were different between the alcohol-treated groups. Glutamic oxaloacetic transaminase and glutamic pyruvic transaminase were more elevated in the sake group than in the other groups. Additionally, liver fibrosis was more pronounced, and vacuole formation or steatosis was less in this group. These results suggest that sake is more fibrogenic. Some components other than ethanol, such as long-alkyl chain alcohols, may have been responsible for the differential histopathology.</p>
キーワード alcoholic liver injury alcoholic beverages alcoholic liver fibrosis longchain alcohols rats
Amo Type Article
発行日 1984-12
出版物タイトル Acta Medica Okayama
38巻
6号
出版者 Okayama University Medical School
開始ページ 493
終了ページ 499
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6524445
Web of Sience KeyUT A1984TX98000001