JaLCDOI 10.18926/AMO/32448
フルテキストURL fulltext.pdf
著者 Ogawa, Hiromichi| Itoshima, Tatsuya| Ito, Toshio| Kiyotoshi, Syozo| Kawaguchi, Kenji| Kitadai, Masahiro| Hattori, Syozo| Mizutani, SHigeki| Ukida, Minoru| Tobe, Kazuo| Nagashima, Hideo| Kobayashi, Toshinari|
抄録 <p>Absence of Kupffer cells in rat liver hyperplastic nodules induced by a chemical carcinogen was demonstrated by intravenous injection of indian ink. Hyperplastic nodules appeared 4 weeks after diethylnitrosamine (DEN) was administered, and the nodules continued growing and became eosinophilic hyperplastic nodules after 5 to 6 weeks. After intravenous injection of indian ink, hyperplastic nodules were observed as carbon-free white nodules, which were macroscopically distinguishable from the black surrounding tissue. As observed by light microscopy, Kupffer cells were absent in hyperplastic nodules in contrast to being present in the surrounding tissue. Scanning electron microscopy confirmed these findings and furthermore revealed that the sinusoidal endothelium of hyperplastic nodules had no fenestrae. Injection of indian ink is a useful method for delineation and enucleation of hyperplastic nodules in the study of morphological and chemical changes of nodules.</p>
キーワード liver hyperplastic nodule kupffer cell chemical carcinogenesis indian ink
Amo Type Article
発行日 1983-02
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 79
終了ページ 84
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6846054
Web of Sience KeyUT A1983QD83600010