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ID 30349
JaLCDOI
フルテキストURL
著者
Hashimoto, Kozo Okayama University
Murakami, Kazuharu Okayama University
Hattori, Teruhiko Okayama University
Ota, Zensuke Okayama University
抄録

Plasma immunoreactive CRF measured by radioimmunoassay decreased rapidly after intravenous injection of synthetic ovine corticotropin releasing factor (CRF) and showed a bi-exponential decay curve in five macaca fuscatas. Half lives of plasma immunoreactive CRF were 5.8 +/- 1.4 (Mean +/- SEM) min for the fast component and 38.3 +/- 2.4 min for the slow component. A bolus injection of 5 micrograms/kg CRF significantly increased the plasma cortisol level. CRF at 5 micrograms/kg induced a delayed response of ACTH and cortisol. Arginine vasopressin (AVP) at 0.5 micrograms/kg induced a slight increase in plasma ACTH and cortisol, but AVP at 0.1 micrograms/kg evoked no significant increase. When 0.5 micrograms/kg CRF and 0.1 micrograms/kg AVP were administered simultaneously, significant ACTH and cortisol responses occurred. The results indicate that CRF and AVP act synergistically to stimulate ACTH secretion in vivo.

キーワード
corticotropin releasing factor
arginine vasopressin
adrenocorticotropin
cortisol
macaca fuscata
Amo Type
Article
発行日
1984-06
出版物タイトル
Acta Medica Okayama
38巻
3号
出版者
Okayama University Medical School
開始ページ
261
終了ページ
267
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT