JaLCDOI 10.18926/AMO/31950
フルテキストURL fulltext.pdf
著者 Wu, Di| Miyamoto, Osamu| Shibuya, Sei| Okada, Maiko| Igawa, Hiroharu| Janjua, Najima A.| Norimatsu, Hiromichi| Itano, Toshifumi|
抄録 <p>Macrophages and microglia are implicated in spinal cord injury, but their precise role is not clear. In the present study, activation of these cells was examined in a spinal cord injury model using 2 different antibodies against ED1 clone and ionized calcium binding adaptor molecule 1 (Iba1). Activation was observed at 1, 4, 8, and 12 weeks after contusion injury and was compared with sham operated controls. Our results indicate that activation could be observed in both the dorsal funiculus and the ventral white matter area in the spinal cord at 5 mm rostral to the epicenter of injury. For both cells, there was a gradual increase in activation from 1-4 weeks, followed by down-regulation for up to 12 weeks. As a result, we could stain macrophages by ED1 and microglia by Iba1. We concluded that macrophages may play a role in the phagocytosis of denatured dendrites after spinal cord injury, while microglia may have some cooperative functions, as they were found scattered near the macrophages.</p>
キーワード macrophages microglia spinal cord injury ED1 Iba1
Amo Type Article
発行日 2005-08
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 121
終了ページ 127
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 16155637
Web of Science KeyUT 000231478000002