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ID 30728
JaLCDOI
フルテキストURL
著者
Sato, Hitoshi Okayama University
Taga, Ichiro Kawasumi Laboratories INC.
Kinoshita, Takahiro Okayama University
Funakubo, Akio Tokyo Denki University
Ichiba, Shingo Okayama University
Shimizu, Nobuyoshi Okayama University
抄録
A prototype of an implantable artificial lung without a pump (Prototype II) has been tested. A commercially available membrane oxygenator, MENOX AL6000alpha R (Dainippon Ink and Chemicals, Inc., Tokyo, Japan), was used as a basic model. The packing density of the hollow fiber was decreased in order to achieve low resistance through the blood pathway. The configuration of its housing was also re-designed using computational fluid dynamics (CFD). The first prototype, known as Prototype I, was already tested in a 15 kg pig, which showed excellent gas exchange with normal hemodynamics. A second prototype, Prototype II, has a larger membrane surface area than Prototype I. The device was evaluated for resistance through the blood path and gas transfer rate in an in vitro setting by the single pass method using fresh bovine blood. The resistance through the blood path of Prototype II was 2.7+- 0.7 mmHg/(L/min) at Q = 5L/min. The oxygen (O2) transfer rate was 178 +- 5.3 ml/min at Q = 5 L/min, V/Q = 3, and the carbon dioxide (CO2) transfer rate was 149 +- 28 ml/min at Q = 5 L/min, V/Q = 2 (Q : blood flow rate, V : sweep oxygen flow rate through the artificial lung). For the purpose of implantation, this prototype showed sufficiently low resistance in the pulmonary circulation with reasonable gas exchange.
キーワード
artificial lung
low resistance
gas exchange
computer fluid dynamics
Amo Type
Article
発行日
2006-04
出版物タイトル
Acta Medica Okayama
60巻
2号
出版者
Okayama University Medical School
開始ページ
113
終了ページ
119
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT