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ID 14402
Eprint ID
14402
フルテキストURL
Thumnail 104_375.pdf 2.41 MB
タイトル(別表記)
Studies on transferrin receptor of macrophages in iron metabolism Part 1. Localization of tranferrin receptors on several kinds of macorophages
著者
稲田 俊雄 岡山大学医学部第二内科学教室
抄録
The delivery of iron into cells is mediated by transferrin via its receptors that reside on the cell surface. To clarify the role of reticuloendothelial cells in iron metabolism, the distribution of transferrin receptors on macrophages in various organs and on peripheral blood monocytes was examined by scanning electron microscopy and radiobinding assay. Radiobinding assay of human alveolar macrophages revealed the presence of 19.88±8.19×10(4) diferric trabsferrin receptors per cell (mean±SD) and a binding constant of 4.42±3.41×10(8)M(-1). Human peritoneal macrophages and macrophages in the thoracic cavity had fewer diferric transferrin receptors (2.68×10(4), 8.10×10(4), 4.3×10(3) and 2.1×10(4) receptors/cell). Peripheral blood monocytes had no diferric transferrin receptors. Diferric transferrin receptors were also found on guinea pig alveolar macrophages (2.25±0.78×10(4)) and peritoneal macrophages (1.6±0.2×10(3)), while they were absent on rat alveolar and peritoneal macro-phages. Scanning electron microscopic findings in guinea pig alveolar macrophages revealed a patch-formed distribution of apotransferrin receptors and diferric transferrin receptors on the characteristic ruffle-covered surface of macrophages. The number of transferrin rece-ptors varied among individual cells even within the same species or same organs. These findings suggest that the macrophages with transferrin receptors in various organs of human and guinea pigs are heterogeneous among different species and cells, and have different functions in iron metabolism.
キーワード
Transferrin receptor
RIA
SEM
Macrophage
Monocyte
発行日
1992
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
104巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
375
終了ページ
386
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/104/3-4/104_3-4_375/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
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言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma